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ARHGAP32

GENERAL INFORMATION

Gene name

 ARHGAP32

Gene description

 Rho GTPase activating protein 32

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA038382 , HPA038389 , HPA061505
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038382
HPA038389
HPA061505

GENE INFORMATION

Gene name

 ARHGAP32 (HGNC Symbol)

Synonyms

 GC-GAP, GRIT, KIAA0712, MGC1892, RICS

Description

 Rho GTPase activating protein 32 (HGNC Symbol)

Entrez gene summary

 RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]

Chromosome

 11

Cytoband

 q24.3

Chromosome location (bp)

 128965060 - 129279324

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134909 (version 83.38)

Entrez gene

 9743

UniProt

 A7KAX9 (UniProt - Evidence at protein level)

neXtProt

 NX_A7KAX9

Antibodypedia

 ARHGAP32 antibodies

PROTEIN BROWSER
ARHGAP32-001
ARHGAP32-002
ARHGAP32-005
ARHGAP32-006
ARHGAP32-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGAP32-001
ENSP00000310561
ENST00000310343
A7KAX9 [Direct mapping]
Rho GTPase-activating protein 32
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Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010008 [endosome membrane]
GO:0014069 [postsynaptic density]
GO:0015629 [actin cytoskeleton]
GO:0030054 [cell junction]
GO:0035091 [phosphatidylinositol binding]
GO:0043197 [dendritic spine]
GO:0043547 [positive regulation of GTPase activity]
GO:0045211 [postsynaptic membrane]
GO:0051056 [regulation of small GTPase mediated signal transduction]
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 2087 aa
230.5 kDa 		No 0
ARHGAP32-002
ENSP00000432862
ENST00000527272
A7KAX9 [Direct mapping]
Rho GTPase-activating protein 32
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010008 [endosome membrane]
GO:0014069 [postsynaptic density]
GO:0030054 [cell junction]
GO:0035091 [phosphatidylinositol binding]
GO:0043197 [dendritic spine]
GO:0043547 [positive regulation of GTPase activity]
GO:0045211 [postsynaptic membrane]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 1738 aa
191 kDa 		No 0
ARHGAP32-005
ENSP00000432468
ENST00000524655
G3V174 [Direct mapping]
Rho GTPase-activating protein 32; Rho GTPase-activating protein, isoform CRA_b
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Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0035091 [phosphatidylinositol binding]
Show all
 946 aa
104.6 kDa 		No 0
ARHGAP32-006
ENSP00000376425
ENST00000392657
A7KAX9 [Direct mapping]
Rho GTPase-activating protein 32
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010008 [endosome membrane]
GO:0014069 [postsynaptic density]
GO:0030054 [cell junction]
GO:0035091 [phosphatidylinositol binding]
GO:0043197 [dendritic spine]
GO:0043547 [positive regulation of GTPase activity]
GO:0045211 [postsynaptic membrane]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 1738 aa
191 kDa 		No 0
ARHGAP32-009
ENSP00000432303
ENST00000525234
E9PRH3 [Direct mapping]
Rho GTPase-activating protein 32
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0035091 [phosphatidylinositol binding]
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 178 aa
20.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.