We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Immunostaining of ANXA1 in the four-stage BJ cell line model for malignant transformation (PMID: 10440377). A strong staining of ANXA1 is observed in the plasma membrane and nucleus of the primary cells, whereas only nuclear staining is observed in the immortalized cells, indicating a translocation of ANXA1.
Immunostaining of ANXA1 in the four-stage BJ cell line model for malignant transformation (PMID: 10440377). A strong staining of ANXA1 is observed in the plasma membrane and nucleus of the primary cells, whereas only nuclear staining is observed in the immortalized cells, indicating a translocation of ANXA1.
Immunostaining of ANXA1 in the four-stage BJ cell line model for malignant transformation (PMID: 10440377). A strong staining of ANXA1 is observed in the plasma membrane and nucleus of the primary cells, whereas only nuclear staining is observed in the immortalized cells, indicating a translocation of ANXA1.
Immunostaining of ANXA1 in the four-stage BJ cell line model for malignant transformation (PMID: 10440377). A strong staining of ANXA1 is observed in the plasma membrane and nucleus of the primary cells, whereas only nuclear staining is observed in the immortalized cells, indicating a translocation of ANXA1.
GENE INFORMATION
Gene name
ANXA1 (HGNC Symbol)
Synonyms
ANX1, LPC1
Description
Annexin A1 (HGNC Symbol)
Entrez gene summary
This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001533 [cornified envelope] GO:0001780 [neutrophil homeostasis] GO:0002548 [monocyte chemotaxis] GO:0002685 [regulation of leukocyte migration] GO:0005102 [receptor binding] GO:0005198 [structural molecule activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006909 [phagocytosis] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0016328 [lateral plasma membrane] GO:0018149 [peptide cross-linking] GO:0019834 [phospholipase A2 inhibitor activity] GO:0019898 [extrinsic component of membrane] GO:0030216 [keratinocyte differentiation] GO:0030674 [protein binding, bridging] GO:0031232 [extrinsic component of external side of plasma membrane] GO:0031313 [extrinsic component of endosome membrane] GO:0031340 [positive regulation of vesicle fusion] GO:0031514 [motile cilium] GO:0031532 [actin cytoskeleton reorganization] GO:0031901 [early endosome membrane] GO:0031982 [vesicle] GO:0032652 [regulation of interleukin-1 production] GO:0032743 [positive regulation of interleukin-2 production] GO:0042102 [positive regulation of T cell proliferation] GO:0043066 [negative regulation of apoptotic process] GO:0045627 [positive regulation of T-helper 1 cell differentiation] GO:0045629 [negative regulation of T-helper 2 cell differentiation] GO:0045920 [negative regulation of exocytosis] GO:0046632 [alpha-beta T cell differentiation] GO:0046883 [regulation of hormone secretion] GO:0048306 [calcium-dependent protein binding] GO:0050727 [regulation of inflammatory response] GO:0070062 [extracellular exosome] GO:0071385 [cellular response to glucocorticoid stimulus] GO:0071621 [granulocyte chemotaxis] GO:0090303 [positive regulation of wound healing] GO:0097350 [neutrophil clearance] GO:2000483 [negative regulation of interleukin-8 secretion]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000733 [DNA strand renaturation] GO:0001533 [cornified envelope] GO:0001780 [neutrophil homeostasis] GO:0002548 [monocyte chemotaxis] GO:0002685 [regulation of leukocyte migration] GO:0003697 [single-stranded DNA binding] GO:0003727 [single-stranded RNA binding] GO:0004386 [helicase activity] GO:0005102 [receptor binding] GO:0005198 [structural molecule activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006909 [phagocytosis] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0008360 [regulation of cell shape] GO:0009725 [response to hormone] GO:0009986 [cell surface] GO:0010165 [response to X-ray] GO:0014070 [response to organic cyclic compound] GO:0014839 [myoblast migration involved in skeletal muscle regeneration] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0016328 [lateral plasma membrane] GO:0018149 [peptide cross-linking] GO:0019834 [phospholipase A2 inhibitor activity] GO:0019898 [extrinsic component of membrane] GO:0030073 [insulin secretion] GO:0030216 [keratinocyte differentiation] GO:0030674 [protein binding, bridging] GO:0030850 [prostate gland development] GO:0031018 [endocrine pancreas development] GO:0031232 [extrinsic component of external side of plasma membrane] GO:0031313 [extrinsic component of endosome membrane] GO:0031340 [positive regulation of vesicle fusion] GO:0031394 [positive regulation of prostaglandin biosynthetic process] GO:0031514 [motile cilium] GO:0031532 [actin cytoskeleton reorganization] GO:0031901 [early endosome membrane] GO:0031960 [response to corticosteroid] GO:0031966 [mitochondrial membrane] GO:0031982 [vesicle] GO:0032355 [response to estradiol] GO:0032508 [DNA duplex unwinding] GO:0032652 [regulation of interleukin-1 production] GO:0032743 [positive regulation of interleukin-2 production] GO:0033031 [positive regulation of neutrophil apoptotic process] GO:0033676 [double-stranded DNA-dependent ATPase activity] GO:0036292 [DNA rewinding] GO:0036310 [annealing helicase activity] GO:0042063 [gliogenesis] GO:0042102 [positive regulation of T cell proliferation] GO:0042127 [regulation of cell proliferation] GO:0042383 [sarcolemma] GO:0042493 [response to drug] GO:0042629 [mast cell granule] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043434 [response to peptide hormone] GO:0044849 [estrous cycle] GO:0045627 [positive regulation of T-helper 1 cell differentiation] GO:0045629 [negative regulation of T-helper 2 cell differentiation] GO:0045920 [negative regulation of exocytosis] GO:0046632 [alpha-beta T cell differentiation] GO:0046883 [regulation of hormone secretion] GO:0048306 [calcium-dependent protein binding] GO:0050482 [arachidonic acid secretion] GO:0050709 [negative regulation of protein secretion] GO:0050727 [regulation of inflammatory response] GO:0051384 [response to glucocorticoid] GO:0070062 [extracellular exosome] GO:0070301 [cellular response to hydrogen peroxide] GO:0070365 [hepatocyte differentiation] GO:0070459 [prolactin secretion] GO:0070555 [response to interleukin-1] GO:0071385 [cellular response to glucocorticoid stimulus] GO:0071621 [granulocyte chemotaxis] GO:0090303 [positive regulation of wound healing] GO:0097350 [neutrophil clearance] GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle] GO:1900138 [negative regulation of phospholipase A2 activity] GO:2000483 [negative regulation of interleukin-8 secretion]