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This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001533 [cornified envelope] GO:0001780 [neutrophil homeostasis] GO:0002548 [monocyte chemotaxis] GO:0002685 [regulation of leukocyte migration] GO:0005102 [receptor binding] GO:0005198 [structural molecule activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006909 [phagocytosis] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0016328 [lateral plasma membrane] GO:0018149 [peptide cross-linking] GO:0019834 [phospholipase A2 inhibitor activity] GO:0019898 [extrinsic component of membrane] GO:0030216 [keratinocyte differentiation] GO:0030674 [protein binding, bridging] GO:0031232 [extrinsic component of external side of plasma membrane] GO:0031313 [extrinsic component of endosome membrane] GO:0031340 [positive regulation of vesicle fusion] GO:0031514 [motile cilium] GO:0031532 [actin cytoskeleton reorganization] GO:0031901 [early endosome membrane] GO:0031982 [vesicle] GO:0032652 [regulation of interleukin-1 production] GO:0032743 [positive regulation of interleukin-2 production] GO:0042102 [positive regulation of T cell proliferation] GO:0043066 [negative regulation of apoptotic process] GO:0045627 [positive regulation of T-helper 1 cell differentiation] GO:0045629 [negative regulation of T-helper 2 cell differentiation] GO:0045920 [negative regulation of exocytosis] GO:0046632 [alpha-beta T cell differentiation] GO:0046883 [regulation of hormone secretion] GO:0048306 [calcium-dependent protein binding] GO:0050727 [regulation of inflammatory response] GO:0070062 [extracellular exosome] GO:0071385 [cellular response to glucocorticoid stimulus] GO:0071621 [granulocyte chemotaxis] GO:0090303 [positive regulation of wound healing] GO:0097350 [neutrophil clearance] GO:2000483 [negative regulation of interleukin-8 secretion]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
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GO:0000733 [DNA strand renaturation] GO:0001533 [cornified envelope] GO:0001780 [neutrophil homeostasis] GO:0002548 [monocyte chemotaxis] GO:0002685 [regulation of leukocyte migration] GO:0003697 [single-stranded DNA binding] GO:0003727 [single-stranded RNA binding] GO:0004386 [helicase activity] GO:0005102 [receptor binding] GO:0005198 [structural molecule activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006909 [phagocytosis] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0008360 [regulation of cell shape] GO:0009725 [response to hormone] GO:0009986 [cell surface] GO:0010165 [response to X-ray] GO:0014070 [response to organic cyclic compound] GO:0014839 [myoblast migration involved in skeletal muscle regeneration] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0016328 [lateral plasma membrane] GO:0018149 [peptide cross-linking] GO:0019834 [phospholipase A2 inhibitor activity] GO:0019898 [extrinsic component of membrane] GO:0030073 [insulin secretion] GO:0030216 [keratinocyte differentiation] GO:0030674 [protein binding, bridging] GO:0030850 [prostate gland development] GO:0031018 [endocrine pancreas development] GO:0031232 [extrinsic component of external side of plasma membrane] GO:0031313 [extrinsic component of endosome membrane] GO:0031340 [positive regulation of vesicle fusion] GO:0031394 [positive regulation of prostaglandin biosynthetic process] GO:0031514 [motile cilium] GO:0031532 [actin cytoskeleton reorganization] GO:0031901 [early endosome membrane] GO:0031960 [response to corticosteroid] GO:0031966 [mitochondrial membrane] GO:0031982 [vesicle] GO:0032355 [response to estradiol] GO:0032508 [DNA duplex unwinding] GO:0032652 [regulation of interleukin-1 production] GO:0032743 [positive regulation of interleukin-2 production] GO:0033031 [positive regulation of neutrophil apoptotic process] GO:0033676 [double-stranded DNA-dependent ATPase activity] GO:0036292 [DNA rewinding] GO:0036310 [annealing helicase activity] GO:0042063 [gliogenesis] GO:0042102 [positive regulation of T cell proliferation] GO:0042127 [regulation of cell proliferation] GO:0042383 [sarcolemma] GO:0042493 [response to drug] GO:0042629 [mast cell granule] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043434 [response to peptide hormone] GO:0044849 [estrous cycle] GO:0045627 [positive regulation of T-helper 1 cell differentiation] GO:0045629 [negative regulation of T-helper 2 cell differentiation] GO:0045920 [negative regulation of exocytosis] GO:0046632 [alpha-beta T cell differentiation] GO:0046883 [regulation of hormone secretion] GO:0048306 [calcium-dependent protein binding] GO:0050482 [arachidonic acid secretion] GO:0050709 [negative regulation of protein secretion] GO:0050727 [regulation of inflammatory response] GO:0051384 [response to glucocorticoid] GO:0070062 [extracellular exosome] GO:0070301 [cellular response to hydrogen peroxide] GO:0070365 [hepatocyte differentiation] GO:0070459 [prolactin secretion] GO:0070555 [response to interleukin-1] GO:0071385 [cellular response to glucocorticoid stimulus] GO:0071621 [granulocyte chemotaxis] GO:0090303 [positive regulation of wound healing] GO:0097350 [neutrophil clearance] GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle] GO:1900138 [negative regulation of phospholipase A2 activity] GO:2000483 [negative regulation of interleukin-8 secretion]