Expression of GOLM1 in cancer - Summary - The Human Protein Atlas

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GOLM1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GOLM1
Gene description	Golgi membrane protein 1
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA010638 , HPA011929 , CAB015341
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and liver cancer (unfavourable).
Endometrial cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA010638	HPA011929	CAB015341

GENE INFORMATION
Gene name	GOLM1 (HGNC Symbol)
Synonyms	bA379P1.3, C9orf155, FLJ23608, GOLPH2, GP73
Description	Golgi membrane protein 1 (HGNC Symbol)
Entrez gene summary	The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Sep 2009]
Chromosome	9
Cytoband	q21.33
Chromosome location (bp)	86026146 - 86100173
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135052 (version 83.38)
Entrez gene	51280
UniProt	Q8NBJ4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NBJ4
Antibodypedia	GOLM1 antibodies

PROTEIN BROWSER

GOLM1-001	GOLM1-002	GOLM1-005	GOLM1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GOLM1-001 ENSP00000373364 ENST00000388712	Q8NBJ4 [Direct mapping] Golgi membrane protein 1 B3KNK9 [Target identity:100%; Query identity:100%] Epididymis luminal protein 46; Golgi phosphoprotein 2, isoform CRA_a; cDNA FLJ14811 fis, clone NT2RP4001975, highly similar to Golgi phosphoprotein 2; cDNA PSEC0257 fis, clone NT2RP3003642, highly similar to golgi phosphoprotein 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005794 [Golgi apparatus] GO:0005887 [integral component of plasma membrane] GO:0006997 [nucleus organization] GO:0019216 [regulation of lipid metabolic process] GO:0070062 [extracellular exosome] Show all	401 aa 45.3 kDa	Yes	0
GOLM1-002 ENSP00000373363 ENST00000388711	Q8NBJ4 [Direct mapping] Golgi membrane protein 1 B3KNK9 [Target identity:100%; Query identity:100%] Epididymis luminal protein 46; Golgi phosphoprotein 2, isoform CRA_a; cDNA FLJ14811 fis, clone NT2RP4001975, highly similar to Golgi phosphoprotein 2; cDNA PSEC0257 fis, clone NT2RP3003642, highly similar to golgi phosphoprotein 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005794 [Golgi apparatus] GO:0005887 [integral component of plasma membrane] GO:0070062 [extracellular exosome] Show all	401 aa 45.3 kDa	Yes	0
GOLM1-005 ENSP00000418155 ENST00000466178	C9J941 [Direct mapping] Golgi membrane protein 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		80 aa 9 kDa	Yes	0
GOLM1-006 ENSP00000419076 ENST00000486130	C9JYM4 [Direct mapping] Golgi membrane protein 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		121 aa 13.7 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.