Expression of CPM in cancer - Summary - The Human Protein Atlas

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CPM

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CPM
Gene description	Carboxypeptidase M
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, SiHa)
HPA (normal tissue):	Tissue enhanced (adipose tissue)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in endometrial glands and fallopian tube.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Caution, Splice and/or transcript discrepancy exists. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA002657
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Endometrial cancer

STAINING SUMMARY

HPA002657

GENE INFORMATION
Gene name	CPM
Synonyms
Description	Carboxypeptidase M (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q15
Chromosome location (bp)	68842197 - 68971570
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135678 (version 83.38)
Entrez gene	1368
UniProt	P14384 (UniProt - Evidence at protein level)
neXtProt	NX_P14384
Antibodypedia	CPM antibodies

PROTEIN BROWSER

CPM-001	CPM-002	CPM-005	CPM-007	CPM-009	CPM-011	CPM-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPM-001 ENSP00000448517 ENST00000551568	P14384 [Direct mapping] Carboxypeptidase M Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0004185 [serine-type carboxypeptidase activity] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0009653 [anatomical structure morphogenesis] GO:0009986 [cell surface] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] Show all	443 aa 50.5 kDa	Yes	1
CPM-002 ENSP00000447255 ENST00000546373	P14384 [Direct mapping] Carboxypeptidase M Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0004185 [serine-type carboxypeptidase activity] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0009653 [anatomical structure morphogenesis] GO:0009986 [cell surface] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] Show all	443 aa 50.5 kDa	Yes	1
CPM-005 ENSP00000446799 ENST00000548954	F8W111 [Direct mapping] Carboxypeptidase M Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	249 aa 28.3 kDa	Yes	0
CPM-007 ENSP00000449911 ENST00000548262	F8VVI6 [Direct mapping] Carboxypeptidase M Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	136 aa 15.4 kDa	Yes	0
CPM-009 ENSP00000448078 ENST00000549781	F8VU13 [Direct mapping] Carboxypeptidase M Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	72 aa 8.1 kDa	Yes	0
CPM-011 ENSP00000447455 ENST00000551897	H0YHN7 [Direct mapping] Carboxypeptidase M Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	198 aa 22.6 kDa	No	0
CPM-201 ENSP00000339157 ENST00000338356	P14384 [Direct mapping] Carboxypeptidase M Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0004185 [serine-type carboxypeptidase activity] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0009653 [anatomical structure morphogenesis] GO:0009986 [cell surface] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] Show all	443 aa 50.5 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
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