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CPM

GENERAL INFORMATION

Gene name

 CPM

Gene description

 Carboxypeptidase M

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (adipose tissue)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Membranous expression in endometrial glands and fallopian tube.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Caution, Splice and/or transcript discrepancy exists. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA002657
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Endometrium

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CPM

Synonyms

Description

 Carboxypeptidase M (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q15

Chromosome location (bp)

 68842197 - 68971570

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135678 (version 83.38)

Entrez gene

 1368

UniProt

 P14384 (UniProt - Evidence at protein level)

neXtProt

 NX_P14384

Antibodypedia

 CPM antibodies

PROTEIN BROWSER
CPM-001
CPM-002
CPM-005
CPM-007
CPM-009
CPM-011
CPM-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CPM-001
ENSP00000448517
ENST00000551568
P14384 [Direct mapping]
Carboxypeptidase M
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004180 [carboxypeptidase activity]
GO:0004181 [metallocarboxypeptidase activity]
GO:0004185 [serine-type carboxypeptidase activity]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
GO:0009653 [anatomical structure morphogenesis]
GO:0009986 [cell surface]
GO:0031225 [anchored component of membrane]
GO:0070062 [extracellular exosome]
Show all
 443 aa
50.5 kDa 		Yes 1
CPM-002
ENSP00000447255
ENST00000546373
P14384 [Direct mapping]
Carboxypeptidase M
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004180 [carboxypeptidase activity]
GO:0004181 [metallocarboxypeptidase activity]
GO:0004185 [serine-type carboxypeptidase activity]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
GO:0009653 [anatomical structure morphogenesis]
GO:0009986 [cell surface]
GO:0031225 [anchored component of membrane]
GO:0070062 [extracellular exosome]
Show all
 443 aa
50.5 kDa 		Yes 1
CPM-005
ENSP00000446799
ENST00000548954
F8W111 [Direct mapping]
Carboxypeptidase M
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004181 [metallocarboxypeptidase activity]
GO:0004185 [serine-type carboxypeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
Show all
 249 aa
28.3 kDa 		Yes 0
CPM-007
ENSP00000449911
ENST00000548262
F8VVI6 [Direct mapping]
Carboxypeptidase M
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004181 [metallocarboxypeptidase activity]
GO:0004185 [serine-type carboxypeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
Show all
 136 aa
15.4 kDa 		Yes 0
CPM-009
ENSP00000448078
ENST00000549781
F8VU13 [Direct mapping]
Carboxypeptidase M
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004181 [metallocarboxypeptidase activity]
GO:0004185 [serine-type carboxypeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
Show all
 72 aa
8.1 kDa 		Yes 0
CPM-011
ENSP00000447455
ENST00000551897
H0YHN7 [Direct mapping]
Carboxypeptidase M
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004181 [metallocarboxypeptidase activity]
GO:0004185 [serine-type carboxypeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
Show all
 198 aa
22.6 kDa 		No 0
CPM-201
ENSP00000339157
ENST00000338356
P14384 [Direct mapping]
Carboxypeptidase M
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004180 [carboxypeptidase activity]
GO:0004181 [metallocarboxypeptidase activity]
GO:0004185 [serine-type carboxypeptidase activity]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
GO:0009653 [anatomical structure morphogenesis]
GO:0009986 [cell surface]
GO:0031225 [anchored component of membrane]
GO:0070062 [extracellular exosome]
Show all
 443 aa
50.5 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.