Expression of GPR55 in cancer - Summary - The Human Protein Atlas

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GPR55

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	GPR55
Gene description	G protein-coupled receptor 55
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HDLM-2, Karpas-707, SK-MEL-30)
HPA (normal tissue):	Tissue enhanced (spleen, testis)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	GPR55
Synonyms
Description	G protein-coupled receptor 55 (HGNC Symbol)
Entrez gene summary	This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013]
Chromosome	2
Cytoband	q37.1
Chromosome location (bp)	230907318 - 230961066
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135898 (version 83.38)
Entrez gene	9290
UniProt	Q9Y2T6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2T6
Antibodypedia	GPR55 antibodies

PROTEIN BROWSER

GPR55-001	GPR55-003	GPR55-201	GPR55-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPR55-001 ENSP00000375893 ENST00000392039	Q9Y2T6 [Direct mapping] G-protein coupled receptor 55 A8K858 [Target identity:100%; Query identity:100%] G protein-coupled receptor 55; G protein-coupled receptor 55, isoform CRA_a; cDNA FLJ75410, highly similar to Homo sapiens G protein-coupled receptor 55, mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004949 [cannabinoid receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0016021 [integral component of membrane] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0038171 [cannabinoid signaling pathway] GO:0045453 [bone resorption] GO:0045671 [negative regulation of osteoclast differentiation] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	319 aa 36.6 kDa	No	7
GPR55-003 ENSP00000412768 ENST00000438398	C9J1P7 [Direct mapping] G-protein-coupled receptor 55 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	242 aa 27.5 kDa	No	6
GPR55-201 ENSP00000375894 ENST00000392040	Q9Y2T6 [Direct mapping] G-protein coupled receptor 55 A8K858 [Target identity:100%; Query identity:100%] G protein-coupled receptor 55; G protein-coupled receptor 55, isoform CRA_a; cDNA FLJ75410, highly similar to Homo sapiens G protein-coupled receptor 55, mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004949 [cannabinoid receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0016021 [integral component of membrane] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0038171 [cannabinoid signaling pathway] GO:0045453 [bone resorption] GO:0045671 [negative regulation of osteoclast differentiation] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	319 aa 36.6 kDa	No	7
GPR55-202 ENSP00000482381 ENST00000622008	Q9Y2T6 [Direct mapping] G-protein coupled receptor 55 A8K858 [Target identity:100%; Query identity:100%] G protein-coupled receptor 55; G protein-coupled receptor 55, isoform CRA_a; cDNA FLJ75410, highly similar to Homo sapiens G protein-coupled receptor 55, mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004949 [cannabinoid receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0016021 [integral component of membrane] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0038171 [cannabinoid signaling pathway] GO:0045453 [bone resorption] GO:0045671 [negative regulation of osteoclast differentiation] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	319 aa 36.6 kDa	No	7

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
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