Tissue expression of GPR55 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GPR55
Gene description	G protein-coupled receptor 55
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (spleen, testis)
GTEx:	Group enriched (caudate, small intestine, spleen, testis)
FANTOM5:	Tissue enhanced (tonsil)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen, testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (caudate, small intestine, spleen, testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (tonsil)

GENE INFORMATION
Gene name	GPR55
Synonyms
Description	G protein-coupled receptor 55 (HGNC Symbol)
Entrez gene summary	This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013]
Chromosome	2
Cytoband	q37.1
Chromosome location (bp)	230907318 - 230961066
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135898 (version 83.38)
Entrez gene	9290
UniProt	Q9Y2T6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2T6
Antibodypedia	GPR55 antibodies

PROTEIN BROWSER

GPR55-001	GPR55-003	GPR55-201	GPR55-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPR55-001 ENSP00000375893 ENST00000392039	Q9Y2T6 [Direct mapping] G-protein coupled receptor 55 A8K858 [Target identity:100%; Query identity:100%] G protein-coupled receptor 55; G protein-coupled receptor 55, isoform CRA_a; cDNA FLJ75410, highly similar to Homo sapiens G protein-coupled receptor 55, mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004949 [cannabinoid receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0016021 [integral component of membrane] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0038171 [cannabinoid signaling pathway] GO:0045453 [bone resorption] GO:0045671 [negative regulation of osteoclast differentiation] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	319 aa 36.6 kDa	No	7
GPR55-003 ENSP00000412768 ENST00000438398	C9J1P7 [Direct mapping] G-protein-coupled receptor 55 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	242 aa 27.5 kDa	No	6
GPR55-201 ENSP00000375894 ENST00000392040	Q9Y2T6 [Direct mapping] G-protein coupled receptor 55 A8K858 [Target identity:100%; Query identity:100%] G protein-coupled receptor 55; G protein-coupled receptor 55, isoform CRA_a; cDNA FLJ75410, highly similar to Homo sapiens G protein-coupled receptor 55, mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004949 [cannabinoid receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0016021 [integral component of membrane] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0038171 [cannabinoid signaling pathway] GO:0045453 [bone resorption] GO:0045671 [negative regulation of osteoclast differentiation] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	319 aa 36.6 kDa	No	7
GPR55-202 ENSP00000482381 ENST00000622008	Q9Y2T6 [Direct mapping] G-protein coupled receptor 55 A8K858 [Target identity:100%; Query identity:100%] G protein-coupled receptor 55; G protein-coupled receptor 55, isoform CRA_a; cDNA FLJ75410, highly similar to Homo sapiens G protein-coupled receptor 55, mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004949 [cannabinoid receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0016021 [integral component of membrane] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0038171 [cannabinoid signaling pathway] GO:0045453 [bone resorption] GO:0045671 [negative regulation of osteoclast differentiation] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	319 aa 36.6 kDa	No	7