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SUCLA2

GENERAL INFORMATION

Gene name

 SUCLA2

Gene description

 Succinate-CoA ligase, ADP-forming, beta subunit

Protein class

 Citric acid cycle related proteins
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA039435 , HPA039536 , HPA061528
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039435
HPA039536
HPA061528

GENE INFORMATION

Gene name

 SUCLA2

Synonyms

Description

 Succinate-CoA ligase, ADP-forming, beta subunit (HGNC Symbol)

Entrez gene summary

 Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q14.2

Chromosome location (bp)

 47936491 - 48001354

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136143 (version 83.38)

Entrez gene

 8803

UniProt

 Q9P2R7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P2R7

Antibodypedia

 SUCLA2 antibodies

PROTEIN BROWSER
SUCLA2-001
SUCLA2-004
SUCLA2-007
SUCLA2-009
SUCLA2-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SUCLA2-001
ENSP00000367923
ENST00000378654
Q9P2R7 [Direct mapping]
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
E5KS60 [Target identity:100%; Query identity:100%]
Succinyl-CoA ligase subunit beta
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Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0004775 [succinate-CoA ligase (ADP-forming) activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006099 [tricarboxylic acid cycle]
GO:0006104 [succinyl-CoA metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006781 [succinyl-CoA pathway]
GO:0008152 [metabolic process]
GO:0043209 [myelin sheath]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
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 463 aa
50.3 kDa 		No 0
SUCLA2-004
ENSP00000488974
ENST00000470760
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005524 [ATP binding]
GO:0046872 [metal ion binding]
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 191 aa
21.1 kDa 		No 0
SUCLA2-007
ENSP00000489055
ENST00000493152
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
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 80 aa
8.6 kDa 		No 0
SUCLA2-009
ENSP00000415091
ENST00000433022
Q5T9Q8 [Direct mapping]
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
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Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
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 154 aa
17.1 kDa 		No 0
SUCLA2-010
ENSP00000392771
ENST00000434484
Q5T9Q5 [Direct mapping]
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
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Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
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 298 aa
32 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.