Cell atlas - RAPGEF5 - The Human Protein Atlas

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RAPGEF5

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	RAPGEF5
Gene description	Rap guanine nucleotide exchange factor (GEF) 5
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins RAS pathway related proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the nuclear bodies.
RNA cell category	Cell line enhanced (SCLC-21H, HUVEC TERT2, U-698)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Nuclear bodies (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA076772
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, HUVEC TERT2, U-698) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the nuclear bodies.

Main location

Nucleoplasm (supported)

Additional location

Nuclear bodies (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA076772	HaCaT	Nucleoplasm
	HPA076772	PC-3	Nucleoplasm
	HPA076772	PC-3	Nuclear bodies
	HPA076772	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	RAPGEF5 (HGNC Symbol)
Synonyms	GFR, KIAA0277, MR-GEF
Description	Rap guanine nucleotide exchange factor (GEF) 5 (HGNC Symbol)
Entrez gene summary	Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
Chromosome	7
Cytoband	p15.3
Chromosome location (bp)	22118238 - 22357144
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136237 (version 83.38)
Entrez gene	9771
UniProt	Q92565 (UniProt - Evidence at protein level)
neXtProt	NX_Q92565
Antibodypedia	RAPGEF5 antibodies

PROTEIN BROWSER

RAPGEF5-001	RAPGEF5-002	RAPGEF5-008	RAPGEF5-009	RAPGEF5-201	RAPGEF5-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RAPGEF5-001 ENSP00000384044 ENST00000401957	Q92565 [Direct mapping] Rap guanine nucleotide exchange factor 5 Show all	Predicted intracellular proteins Plasma proteins RAS pathway related proteins Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005088 [Ras guanyl-nucleotide exchange factor activity] GO:0005634 [nucleus] GO:0007264 [small GTPase mediated signal transduction] GO:0007399 [nervous system development] GO:0017034 [Rap guanyl-nucleotide exchange factor activity] GO:0030742 [GTP-dependent protein binding] GO:0043547 [positive regulation of GTPase activity] Show all	580 aa 67.7 kDa	No	0
RAPGEF5-002 ENSP00000384870 ENST00000405243	E9PGY3 [Direct mapping] Rap guanine nucleotide exchange factor 5 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Show all	GO:0005622 [intracellular] GO:0035556 [intracellular signal transduction] Show all	400 aa 44.7 kDa	Yes	0
RAPGEF5-008 ENSP00000415664 ENST00000458533	C9JBS6 [Direct mapping] Rap guanine nucleotide exchange factor 5 Show all	Predicted intracellular proteins RAS pathway related proteins Show all		142 aa 17.3 kDa	No	0
RAPGEF5-009 ENSP00000395729 ENST00000420196	C9JHM4 [Direct mapping] Rap guanine nucleotide exchange factor 5 Show all	Predicted intracellular proteins RAS pathway related proteins Show all		155 aa 17.8 kDa	No	0
RAPGEF5-201 ENSP00000343656 ENST00000344041	A8MQ07 [Direct mapping] Rap guanine nucleotide exchange factor 5 Show all	SignalP predicted secreted proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	730 aa 84.7 kDa	No	0
RAPGEF5-202 ENSP00000479340 ENST00000620335	Q92565 [Direct mapping] Rap guanine nucleotide exchange factor 5 Show all	Predicted intracellular proteins Plasma proteins RAS pathway related proteins Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005088 [Ras guanyl-nucleotide exchange factor activity] GO:0005634 [nucleus] GO:0007264 [small GTPase mediated signal transduction] GO:0007399 [nervous system development] GO:0017034 [Rap guanyl-nucleotide exchange factor activity] GO:0030742 [GTP-dependent protein binding] GO:0043547 [positive regulation of GTPase activity] Show all	444 aa 52.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.