Expression of RAPGEF5 in cancer - Summary - The Human Protein Atlas

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RAPGEF5

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RAPGEF5
Gene description	Rap guanine nucleotide exchange factor (GEF) 5
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins RAS pathway related proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HUVEC TERT2, SCLC-21H, U-698)
HPA (normal tissue):	Tissue enriched (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA057821
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable) and endometrial cancer (unfavourable).
Head and neck cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA057821

GENE INFORMATION
Gene name	RAPGEF5 (HGNC Symbol)
Synonyms	GFR, KIAA0277, MR-GEF
Description	Rap guanine nucleotide exchange factor (GEF) 5 (HGNC Symbol)
Entrez gene summary	Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
Chromosome	7
Cytoband	p15.3
Chromosome location (bp)	22118238 - 22357144
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136237 (version 83.38)
Entrez gene	9771
UniProt	Q92565 (UniProt - Evidence at protein level)
neXtProt	NX_Q92565
Antibodypedia	RAPGEF5 antibodies

PROTEIN BROWSER

RAPGEF5-001	RAPGEF5-002	RAPGEF5-008	RAPGEF5-009	RAPGEF5-201	RAPGEF5-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RAPGEF5-001 ENSP00000384044 ENST00000401957	Q92565 [Direct mapping] Rap guanine nucleotide exchange factor 5 Show all	Predicted intracellular proteins Plasma proteins RAS pathway related proteins Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005088 [Ras guanyl-nucleotide exchange factor activity] GO:0005634 [nucleus] GO:0007264 [small GTPase mediated signal transduction] GO:0007399 [nervous system development] GO:0017034 [Rap guanyl-nucleotide exchange factor activity] GO:0030742 [GTP-dependent protein binding] GO:0043547 [positive regulation of GTPase activity] Show all	580 aa 67.7 kDa	No	0
RAPGEF5-002 ENSP00000384870 ENST00000405243	E9PGY3 [Direct mapping] Rap guanine nucleotide exchange factor 5 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Show all	GO:0005622 [intracellular] GO:0035556 [intracellular signal transduction] Show all	400 aa 44.7 kDa	Yes	0
RAPGEF5-008 ENSP00000415664 ENST00000458533	C9JBS6 [Direct mapping] Rap guanine nucleotide exchange factor 5 Show all	Predicted intracellular proteins RAS pathway related proteins Show all		142 aa 17.3 kDa	No	0
RAPGEF5-009 ENSP00000395729 ENST00000420196	C9JHM4 [Direct mapping] Rap guanine nucleotide exchange factor 5 Show all	Predicted intracellular proteins RAS pathway related proteins Show all		155 aa 17.8 kDa	No	0
RAPGEF5-201 ENSP00000343656 ENST00000344041	A8MQ07 [Direct mapping] Rap guanine nucleotide exchange factor 5 Show all	SignalP predicted secreted proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	730 aa 84.7 kDa	No	0
RAPGEF5-202 ENSP00000479340 ENST00000620335	Q92565 [Direct mapping] Rap guanine nucleotide exchange factor 5 Show all	Predicted intracellular proteins Plasma proteins RAS pathway related proteins Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005088 [Ras guanyl-nucleotide exchange factor activity] GO:0005634 [nucleus] GO:0007264 [small GTPase mediated signal transduction] GO:0007399 [nervous system development] GO:0017034 [Rap guanyl-nucleotide exchange factor activity] GO:0030742 [GTP-dependent protein binding] GO:0043547 [positive regulation of GTPase activity] Show all	444 aa 52.1 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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