Tissue expression of DGKB - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DGKB
Gene description	Diacylglycerol kinase, beta 90kDa
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (caudate, cerebral cortex, hippocampus, hypothalamus)
FANTOM5:	Group enriched (brain, caudate, hippocampus)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (caudate, cerebral cortex, hippocampus, hypothalamus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (brain, caudate, hippocampus)

GENE INFORMATION
Gene name	DGKB (HGNC Symbol)
Synonyms	DAGK2, DGK, DGK-BETA, KIAA0718
Description	Diacylglycerol kinase, beta 90kDa (HGNC Symbol)
Entrez gene summary	Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	p21.2
Chromosome location (bp)	14145049 - 14974777
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136267 (version 83.38)
Entrez gene	1607
UniProt	Q9Y6T7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9Y6T7
Antibodypedia	DGKB antibodies

PROTEIN BROWSER

DGKB-001	DGKB-002	DGKB-005	DGKB-011	DGKB-013	DGKB-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DGKB-001 ENSP00000385780 ENST00000403951	Q9Y6T7 [Direct mapping] Diacylglycerol kinase beta Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004143 [diacylglycerol kinase activity] GO:0005509 [calcium ion binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007596 [blood coagulation] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0030168 [platelet activation] GO:0035556 [intracellular signal transduction] Show all	804 aa 90.6 kDa	No	0
DGKB-002 ENSP00000386066 ENST00000406247	Q9Y6T7 [Direct mapping] Diacylglycerol kinase beta Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004143 [diacylglycerol kinase activity] GO:0005509 [calcium ion binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007596 [blood coagulation] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0030168 [platelet activation] GO:0035556 [intracellular signal transduction] Show all	773 aa 87.1 kDa	No	0
DGKB-005 ENSP00000405569 ENST00000437998	C9JA18 [Direct mapping] Diacylglycerol kinase beta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		75 aa 8.8 kDa	No	0
DGKB-011 ENSP00000385031 ENST00000407950	B5MCD5 [Direct mapping] Diacylglycerol kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004143 [diacylglycerol kinase activity] GO:0005509 [calcium ion binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0035556 [intracellular signal transduction] Show all	796 aa 89.6 kDa	No	0
DGKB-013 ENSP00000384909 ENST00000402815	B5MBY2 [Direct mapping] Diacylglycerol kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004143 [diacylglycerol kinase activity] GO:0005509 [calcium ion binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0035556 [intracellular signal transduction] Show all	803 aa 90.5 kDa	No	0
DGKB-201 ENSP00000382260 ENST00000399322	Q9Y6T7 [Direct mapping] Diacylglycerol kinase beta Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004143 [diacylglycerol kinase activity] GO:0005509 [calcium ion binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007596 [blood coagulation] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0030168 [platelet activation] GO:0035556 [intracellular signal transduction] Show all	804 aa 90.6 kDa	No	0