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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

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Score

Score

Score

Antibodies

Column

 
 
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ADAMTS7
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADAMTS7

Gene description

ADAM metallopeptidase with thrombospondin type 1 motif, 7

Protein class

Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (HMC-1)
HPA (normal tissue):Tissue enhanced (endometrium)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA045284
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PROGNOSTIC SUMMARY

Prognostic marker in stomach cancer (unfavourable).
Stomach cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA045284

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Weak to moderate nuclear and occasional cytoplasmic immunoreactivity was observed in most cancer tissues. Skin cancers and squamous cell carcinomas of head and neck cancers displayed moderate to strong cytoplasmic positivity. Carcinoids, gliomas, lymphomas, prostate, thyroid and endometrial cancers were generally negative.

GENE INFORMATION

Gene name

ADAMTS7 (HGNC Symbol)

Synonyms

ADAM-TS7, DKFZp434H204

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 7 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two C-terminal TS motifs. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q25.1

Chromosome location (bp)

78759203 - 78811431

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136378 (version 83.38)

Entrez gene

11173

UniProt

Q9UKP4 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UKP4

Antibodypedia

ADAMTS7 antibodies

PROTEIN BROWSER

ADAMTS7-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAMTS7-001
ENSP00000373472
ENST00000388820
Q9UKP4 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 7
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Enzymes
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006493 [protein O-linked glycosylation]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0031012 [extracellular matrix]
GO:0032331 [negative regulation of chondrocyte differentiation]
GO:0036066 [protein O-linked fucosylation]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071773 [cellular response to BMP stimulus]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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1686 aa
184.1 kDa
Yes 0

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