Weak to moderate nuclear and occasional cytoplasmic immunoreactivity was observed in most cancer tissues. Skin cancers and squamous cell carcinomas of head and neck cancers displayed moderate to strong cytoplasmic positivity. Carcinoids, gliomas, lymphomas, prostate, thyroid and endometrial cancers were generally negative.
ADAMTS7 (HGNC Symbol)
ADAM metallopeptidase with thrombospondin type 1 motif, 7 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two C-terminal TS motifs. [provided by RefSeq, Jul 2008]