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ADAMTS7

GENERAL INFORMATION

Gene name

 ADAMTS7

Gene description

 ADAM metallopeptidase with thrombospondin type 1 motif, 7

Protein class

 Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (HMC-1)
HPA (normal tissue):Tissue enhanced (endometrium)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA045284
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PROGNOSTIC SUMMARY
Prognostic marker in stomach cancer (unfavourable).
Stomach cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045284

GENE INFORMATION

Gene name

 ADAMTS7 (HGNC Symbol)

Synonyms

 ADAM-TS7, DKFZp434H204

Description

 ADAM metallopeptidase with thrombospondin type 1 motif, 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two C-terminal TS motifs. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q25.1

Chromosome location (bp)

 78759203 - 78811431

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136378 (version 83.38)

Entrez gene

 11173

UniProt

 Q9UKP4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKP4

Antibodypedia

 ADAMTS7 antibodies

PROTEIN BROWSER
ADAMTS7-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADAMTS7-001
ENSP00000373472
ENST00000388820
Q9UKP4 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 7
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Enzymes
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006493 [protein O-linked glycosylation]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0031012 [extracellular matrix]
GO:0032331 [negative regulation of chondrocyte differentiation]
GO:0036066 [protein O-linked fucosylation]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071773 [cellular response to BMP stimulus]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 1686 aa
184.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.