Tissue expression of ADAMTS7 - Summary - The Human Protein Atlas

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ADAMTS7

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ADAMTS7
Gene description	ADAM metallopeptidase with thrombospondin type 1 motif, 7
Protein class	Enzymes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (endometrium)
GTEx:	Mixed
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA045284
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (endometrium)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	ADAMTS7 (HGNC Symbol)
Synonyms	ADAM-TS7, DKFZp434H204
Description	ADAM metallopeptidase with thrombospondin type 1 motif, 7 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two C-terminal TS motifs. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q25.1
Chromosome location (bp)	78759203 - 78811431
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136378 (version 83.38)
Entrez gene	11173
UniProt	Q9UKP4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UKP4
Antibodypedia	ADAMTS7 antibodies

PROTEIN BROWSER

ADAMTS7-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAMTS7-001 ENSP00000373472 ENST00000388820	Q9UKP4 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 7 Show all	Enzymes Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005788 [endoplasmic reticulum lumen] GO:0006493 [protein O-linked glycosylation] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0009986 [cell surface] GO:0031012 [extracellular matrix] GO:0032331 [negative regulation of chondrocyte differentiation] GO:0036066 [protein O-linked fucosylation] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0071347 [cellular response to interleukin-1] GO:0071356 [cellular response to tumor necrosis factor] GO:0071773 [cellular response to BMP stimulus] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	1686 aa 184.1 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.