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TXN

GENERAL INFORMATION

Gene name

 TXN

Gene description

 Thioredoxin

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic and nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA047478 , HPA055752 , CAB008678
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TXN (HGNC Symbol)

Synonyms

 TRX

Description

 Thioredoxin (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 9

Cytoband

 q31.3

Chromosome location (bp)

 110243811 - 110256640

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136810 (version 83.38)

Entrez gene

 7295

UniProt

 P10599 (UniProt - Evidence at protein level)

neXtProt

 NX_P10599

Antibodypedia

 TXN antibodies

PROTEIN BROWSER
TXN-001
TXN-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TXN-001
ENSP00000363641
ENST00000374517
P10599 [Direct mapping]
Thioredoxin
H9ZYJ2 [Target identity:100%; Query identity:100%]
Thioredoxin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000103 [sulfate assimilation]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000302 [response to reactive oxygen species]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006457 [protein folding]
GO:0006662 [glycerol ether metabolic process]
GO:0006928 [movement of cell or subcellular component]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008283 [cell proliferation]
GO:0009314 [response to radiation]
GO:0010467 [gene expression]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0015037 [peptide disulfide oxidoreductase activity]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor]
GO:0032148 [activation of protein kinase B activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033158 [regulation of protein import into nucleus, translocation]
GO:0034599 [cellular response to oxidative stress]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0043388 [positive regulation of DNA binding]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045454 [cell redox homeostasis]
GO:0046826 [negative regulation of protein export from nucleus]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:1903206 [negative regulation of hydrogen peroxide-induced cell death]
Show all
 105 aa
11.7 kDa 		No 0
TXN-002
ENSP00000363639
ENST00000374515
P10599 [Direct mapping]
Thioredoxin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000103 [sulfate assimilation]
GO:0000302 [response to reactive oxygen species]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006457 [protein folding]
GO:0006662 [glycerol ether metabolic process]
GO:0006928 [movement of cell or subcellular component]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008283 [cell proliferation]
GO:0009314 [response to radiation]
GO:0010467 [gene expression]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor]
GO:0032148 [activation of protein kinase B activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033158 [regulation of protein import into nucleus, translocation]
GO:0034599 [cellular response to oxidative stress]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0043388 [positive regulation of DNA binding]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045454 [cell redox homeostasis]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:1903206 [negative regulation of hydrogen peroxide-induced cell death]
Show all
 85 aa
9.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.