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ITPKA

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GENERAL INFORMATION

Gene name

 ITPKA

Gene description

 Inositol-trisphosphate 3-kinase A

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to vesicles.

RNA cell category

 Cell line enhanced (Hep G2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA040454
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to vesicles.

Main location

 Vesicles (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA040454 A-431 No staining    
HPA040454 U-2 OS Vesicles
HPA040454 U-251 MG Vesicles Intensity

GENE INFORMATION

Gene name

 ITPKA (HGNC Symbol)

Synonyms

 IP3-3KA, IP3KA

Description

 Inositol-trisphosphate 3-kinase A (HGNC Symbol)

Entrez gene summary

 Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]

Chromosome

 15

Cytoband

 q15.1

Chromosome location (bp)

 41493393 - 41503551

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137825 (version 83.38)

Entrez gene

 3706

UniProt

 P23677 (UniProt - Evidence at protein level)

neXtProt

 NX_P23677

Antibodypedia

 ITPKA antibodies

PROTEIN BROWSER
ITPKA-001
ITPKA-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ITPKA-001
ENSP00000260386
ENST00000260386
P23677 [Direct mapping]
Inositol-trisphosphate 3-kinase A
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006020 [inositol metabolic process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0030036 [actin cytoskeleton organization]
GO:0043197 [dendritic spine]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048167 [regulation of synaptic plasticity]
GO:0048365 [Rac GTPase binding]
GO:0061003 [positive regulation of dendritic spine morphogenesis]
GO:0097062 [dendritic spine maintenance]
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 461 aa
51 kDa 		No 0
ITPKA-002
ENSP00000396560
ENST00000425927
C9JC74 [Direct mapping]
Inositol-trisphosphate 3-kinase A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0016310 [phosphorylation]
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 260 aa
29.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.