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ITPKA

GENERAL INFORMATION

Gene name

 ITPKA

Gene description

 Inositol-trisphosphate 3-kinase A

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (Hep G2)
HPA (normal tissue):Tissue enhanced (cerebral cortex, duodenum, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct expression in astrocytes and processes in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA040454
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and glioma (unfavourable).
Renal cancer p<0.001
Glioma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA040454

GENE INFORMATION

Gene name

 ITPKA (HGNC Symbol)

Synonyms

 IP3-3KA, IP3KA

Description

 Inositol-trisphosphate 3-kinase A (HGNC Symbol)

Entrez gene summary

 Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]

Chromosome

 15

Cytoband

 q15.1

Chromosome location (bp)

 41493393 - 41503551

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137825 (version 83.38)

Entrez gene

 3706

UniProt

 P23677 (UniProt - Evidence at protein level)

neXtProt

 NX_P23677

Antibodypedia

 ITPKA antibodies

PROTEIN BROWSER
ITPKA-001
ITPKA-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ITPKA-001
ENSP00000260386
ENST00000260386
P23677 [Direct mapping]
Inositol-trisphosphate 3-kinase A
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006020 [inositol metabolic process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0030036 [actin cytoskeleton organization]
GO:0043197 [dendritic spine]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048167 [regulation of synaptic plasticity]
GO:0048365 [Rac GTPase binding]
GO:0061003 [positive regulation of dendritic spine morphogenesis]
GO:0097062 [dendritic spine maintenance]
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 461 aa
51 kDa 		No 0
ITPKA-002
ENSP00000396560
ENST00000425927
C9JC74 [Direct mapping]
Inositol-trisphosphate 3-kinase A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0016310 [phosphorylation]
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 260 aa
29.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.