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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ADAM10
  • TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADAM10

Gene description

ADAM metallopeptidase domain 10

Protein class

Cancer-related genes
CD markers
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB001709
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in lung cancer (unfavourable) and pancreatic cancer (unfavourable).
Lung cancer p<0.001
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB001709

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few cases of prostate and urothelial cancers showed moderate cytoplasmic positivity. Remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

ADAM10 (HGNC Symbol)

Synonyms

CD156c, HsT18717, kuz, MADM

Description

ADAM metallopeptidase domain 10 (HGNC Symbol)

Entrez gene summary

Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q21.3

Chromosome location (bp)

58588807 - 58749978

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137845 (version 83.38)

Entrez gene

102

UniProt

O14672 (UniProt - Evidence at protein level)

neXtProt

NX_O14672

Antibodypedia

ADAM10 antibodies

PROTEIN BROWSER

ADAM10-001
ADAM10-003
ADAM10-006
ADAM10-010
ADAM10-013
ADAM10-016
ADAM10-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAM10-001
ENSP00000260408
ENST00000260408
O14672 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 10
A0A024R5U5 [Target identity:100%; Query identity:100%]
ADAM metallopeptidase domain 10, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001701 [in utero embryonic development]
GO:0004175 [endopeptidase activity]
GO:0004222 [metalloendopeptidase activity]
GO:0005102 [receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005798 [Golgi-associated vesicle]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006508 [proteolysis]
GO:0006509 [membrane protein ectodomain proteolysis]
GO:0007162 [negative regulation of cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0007220 [Notch receptor processing]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007411 [axon guidance]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0009986 [cell surface]
GO:0010820 [positive regulation of T cell chemotaxis]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016485 [protein processing]
GO:0017124 [SH3 domain binding]
GO:0019901 [protein kinase binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030307 [positive regulation of cell growth]
GO:0030335 [positive regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0034612 [response to tumor necrosis factor]
GO:0042117 [monocyte activation]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051088 [PMA-inducible membrane protein ectodomain proteolysis]
GO:0051089 [constitutive protein ectodomain proteolysis]
GO:0070062 [extracellular exosome]
GO:0097038 [perinuclear endoplasmic reticulum]
GO:0097197 [tetraspanin-enriched microdomain]
Show all
748 aa
84.1 kDa
Yes 1
ADAM10-003
ENSP00000481779
ENST00000461408
A0A087WYG1 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 10
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
59 aa
6.4 kDa
Yes 0
ADAM10-006
ENSP00000386056
ENST00000402627
B5MC71 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 10
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
Show all
71 aa
7.5 kDa
Yes 0
ADAM10-010
ENSP00000391930
ENST00000439637
C9J9B4 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 10
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
Show all
125 aa
14.5 kDa
Yes 0
ADAM10-013
ENSP00000452704
ENST00000558004
H0YK87 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 10
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
115 aa
13.2 kDa
Yes 0
ADAM10-016
ENSP00000453952
ENST00000559053
H0YNC5 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 10
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
Show all
148 aa
16 kDa
Yes 0
ADAM10-017
ENSP00000452639
ENST00000561288
H0YK32 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 10
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
38 aa
4.1 kDa
Yes 0

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