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Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ITGAV
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ITGAV

Gene description

Integrin, alpha V

Protein class

Cancer-related genes
CD markers
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (RT4)
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA004856 , CAB002499
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in stomach cancer (unfavourable), liver cancer (unfavourable) and pancreatic cancer (unfavourable).
Stomach cancer p<0.001
Liver cancer p<0.001
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA004856
CAB002499

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of cancer cells displayed weak to moderate cytoplasmic and nuclear immunoreactivity. Gliomas showed strong nuclear staining in several cases. Strong cytoplasmic and membranous staining was observed in several urothelial cancers and melanomas. A majority of testicular, renal and cervical cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer cells showed weak to moderate membranous and cytoplasmic immunoreactivity. Strong positivity was observed in several cases of gliomas, urothelial, renal and skin cancers. Testicular cancers and most cases of lymphomas were negative.

GENE INFORMATION

Gene name

ITGAV (HGNC Symbol)

Synonyms

CD51, MSK8, VNRA, VTNR

Description

Integrin, alpha V (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]

Chromosome

2

Cytoband

q32.1

Chromosome location (bp)

186590065 - 186680901

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138448 (version 83.38)

Entrez gene

3685

UniProt

P06756 (UniProt - Evidence at protein level)

neXtProt

NX_P06756

Antibodypedia

ITGAV antibodies

PROTEIN BROWSER

ITGAV-001
ITGAV-003
ITGAV-004
ITGAV-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ITGAV-001
ENSP00000261023
ENST00000261023
P06756 [Direct mapping]
Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain
L7RXH0 [Target identity:100%; Query identity:100%]
Integrin, alpha V
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001568 [blood vessel development]
GO:0001618 [virus receptor activity]
GO:0001846 [opsonin binding]
GO:0001968 [fibronectin binding]
GO:0002020 [protease binding]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0005080 [protein kinase C binding]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008305 [integrin complex]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010888 [negative regulation of lipid storage]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0016477 [cell migration]
GO:0030198 [extracellular matrix organization]
GO:0030335 [positive regulation of cell migration]
GO:0031258 [lamellipodium membrane]
GO:0031527 [filopodium membrane]
GO:0031528 [microvillus membrane]
GO:0031589 [cell-substrate adhesion]
GO:0031994 [insulin-like growth factor I binding]
GO:0032369 [negative regulation of lipid transport]
GO:0032587 [ruffle membrane]
GO:0033690 [positive regulation of osteoblast proliferation]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034683 [integrin alphav-beta3 complex]
GO:0034684 [integrin alphav-beta5 complex]
GO:0034686 [integrin alphav-beta8 complex]
GO:0035867 [alphav-beta3 integrin-IGF-1-IGF1R complex]
GO:0035987 [endodermal cell differentiation]
GO:0038027 [apolipoprotein A-I-mediated signaling pathway]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0043277 [apoptotic cell clearance]
GO:0045335 [phagocytic vesicle]
GO:0045715 [negative regulation of low-density lipoprotein particle receptor biosynthetic process]
GO:0045785 [positive regulation of cell adhesion]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050431 [transforming growth factor beta binding]
GO:0050748 [negative regulation of lipoprotein metabolic process]
GO:0050764 [regulation of phagocytosis]
GO:0050840 [extracellular matrix binding]
GO:0050900 [leukocyte migration]
GO:0050919 [negative chemotaxis]
GO:0052066 [entry of symbiont into host cell by promotion of host phagocytosis]
GO:0070062 [extracellular exosome]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070588 [calcium ion transmembrane transport]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:1990430 [extracellular matrix protein binding]
GO:2000425 [regulation of apoptotic cell clearance]
GO:2000536 [negative regulation of entry of bacterium into host cell]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
1048 aa
116 kDa
Yes 1
ITGAV-003
ENSP00000364042
ENST00000374907
P06756 [Direct mapping]
Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001618 [virus receptor activity]
GO:0001846 [opsonin binding]
GO:0001968 [fibronectin binding]
GO:0002020 [protease binding]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0005080 [protein kinase C binding]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010888 [negative regulation of lipid storage]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0016477 [cell migration]
GO:0030198 [extracellular matrix organization]
GO:0031258 [lamellipodium membrane]
GO:0031527 [filopodium membrane]
GO:0031528 [microvillus membrane]
GO:0031589 [cell-substrate adhesion]
GO:0031994 [insulin-like growth factor I binding]
GO:0032369 [negative regulation of lipid transport]
GO:0032587 [ruffle membrane]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034683 [integrin alphav-beta3 complex]
GO:0034684 [integrin alphav-beta5 complex]
GO:0034686 [integrin alphav-beta8 complex]
GO:0035867 [alphav-beta3 integrin-IGF-1-IGF1R complex]
GO:0035987 [endodermal cell differentiation]
GO:0038027 [apolipoprotein A-I-mediated signaling pathway]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0045335 [phagocytic vesicle]
GO:0045715 [negative regulation of low-density lipoprotein particle receptor biosynthetic process]
GO:0045785 [positive regulation of cell adhesion]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050431 [transforming growth factor beta binding]
GO:0050748 [negative regulation of lipoprotein metabolic process]
GO:0050764 [regulation of phagocytosis]
GO:0050840 [extracellular matrix binding]
GO:0050900 [leukocyte migration]
GO:0050919 [negative chemotaxis]
GO:0052066 [entry of symbiont into host cell by promotion of host phagocytosis]
GO:0070062 [extracellular exosome]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070588 [calcium ion transmembrane transport]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:1990430 [extracellular matrix protein binding]
GO:2000425 [regulation of apoptotic cell clearance]
GO:2000536 [negative regulation of entry of bacterium into host cell]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
1012 aa
112.3 kDa
Yes 1
ITGAV-004
ENSP00000404291
ENST00000433736
P06756 [Direct mapping]
Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001618 [virus receptor activity]
GO:0001846 [opsonin binding]
GO:0001968 [fibronectin binding]
GO:0002020 [protease binding]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0005080 [protein kinase C binding]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010888 [negative regulation of lipid storage]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0016477 [cell migration]
GO:0030198 [extracellular matrix organization]
GO:0031258 [lamellipodium membrane]
GO:0031527 [filopodium membrane]
GO:0031528 [microvillus membrane]
GO:0031589 [cell-substrate adhesion]
GO:0031994 [insulin-like growth factor I binding]
GO:0032369 [negative regulation of lipid transport]
GO:0032587 [ruffle membrane]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034683 [integrin alphav-beta3 complex]
GO:0034684 [integrin alphav-beta5 complex]
GO:0034686 [integrin alphav-beta8 complex]
GO:0035867 [alphav-beta3 integrin-IGF-1-IGF1R complex]
GO:0035987 [endodermal cell differentiation]
GO:0038027 [apolipoprotein A-I-mediated signaling pathway]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0045335 [phagocytic vesicle]
GO:0045715 [negative regulation of low-density lipoprotein particle receptor biosynthetic process]
GO:0045785 [positive regulation of cell adhesion]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050431 [transforming growth factor beta binding]
GO:0050748 [negative regulation of lipoprotein metabolic process]
GO:0050764 [regulation of phagocytosis]
GO:0050840 [extracellular matrix binding]
GO:0050900 [leukocyte migration]
GO:0050919 [negative chemotaxis]
GO:0052066 [entry of symbiont into host cell by promotion of host phagocytosis]
GO:0070062 [extracellular exosome]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070588 [calcium ion transmembrane transport]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:1990430 [extracellular matrix protein binding]
GO:2000425 [regulation of apoptotic cell clearance]
GO:2000536 [negative regulation of entry of bacterium into host cell]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
1002 aa
111.1 kDa
Yes 1
ITGAV-008
ENSP00000389442
ENST00000430709
H7BZG1 [Direct mapping]
Integrin alpha-V
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
136 aa
15.3 kDa
No 0

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