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ITGAV

GENERAL INFORMATION

Gene name

 ITGAV

Gene description

 Integrin, alpha V

Protein class

 Cancer-related genes
CD markers
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA004856 , CAB002499
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ITGAV (HGNC Symbol)

Synonyms

 CD51, MSK8, VNRA, VTNR

Description

 Integrin, alpha V (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]

Chromosome

 2

Cytoband

 q32.1

Chromosome location (bp)

 186590065 - 186680901

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138448 (version 83.38)

Entrez gene

 3685

UniProt

 P06756 (UniProt - Evidence at protein level)

neXtProt

 NX_P06756

Antibodypedia

 ITGAV antibodies

PROTEIN BROWSER
ITGAV-001
ITGAV-003
ITGAV-004
ITGAV-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ITGAV-001
ENSP00000261023
ENST00000261023
P06756 [Direct mapping]
Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain
L7RXH0 [Target identity:100%; Query identity:100%]
Integrin, alpha V
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001568 [blood vessel development]
GO:0001618 [virus receptor activity]
GO:0001846 [opsonin binding]
GO:0001968 [fibronectin binding]
GO:0002020 [protease binding]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0005080 [protein kinase C binding]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008305 [integrin complex]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010888 [negative regulation of lipid storage]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0016477 [cell migration]
GO:0030198 [extracellular matrix organization]
GO:0030335 [positive regulation of cell migration]
GO:0031258 [lamellipodium membrane]
GO:0031527 [filopodium membrane]
GO:0031528 [microvillus membrane]
GO:0031589 [cell-substrate adhesion]
GO:0031994 [insulin-like growth factor I binding]
GO:0032369 [negative regulation of lipid transport]
GO:0032587 [ruffle membrane]
GO:0033690 [positive regulation of osteoblast proliferation]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034683 [integrin alphav-beta3 complex]
GO:0034684 [integrin alphav-beta5 complex]
GO:0034686 [integrin alphav-beta8 complex]
GO:0035867 [alphav-beta3 integrin-IGF-1-IGF1R complex]
GO:0035987 [endodermal cell differentiation]
GO:0038027 [apolipoprotein A-I-mediated signaling pathway]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0043277 [apoptotic cell clearance]
GO:0045335 [phagocytic vesicle]
GO:0045715 [negative regulation of low-density lipoprotein particle receptor biosynthetic process]
GO:0045785 [positive regulation of cell adhesion]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050431 [transforming growth factor beta binding]
GO:0050748 [negative regulation of lipoprotein metabolic process]
GO:0050764 [regulation of phagocytosis]
GO:0050840 [extracellular matrix binding]
GO:0050900 [leukocyte migration]
GO:0050919 [negative chemotaxis]
GO:0052066 [entry of symbiont into host cell by promotion of host phagocytosis]
GO:0070062 [extracellular exosome]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070588 [calcium ion transmembrane transport]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:1990430 [extracellular matrix protein binding]
GO:2000425 [regulation of apoptotic cell clearance]
GO:2000536 [negative regulation of entry of bacterium into host cell]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 1048 aa
116 kDa 		Yes 1
ITGAV-003
ENSP00000364042
ENST00000374907
P06756 [Direct mapping]
Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001618 [virus receptor activity]
GO:0001846 [opsonin binding]
GO:0001968 [fibronectin binding]
GO:0002020 [protease binding]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0005080 [protein kinase C binding]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010888 [negative regulation of lipid storage]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0016477 [cell migration]
GO:0030198 [extracellular matrix organization]
GO:0031258 [lamellipodium membrane]
GO:0031527 [filopodium membrane]
GO:0031528 [microvillus membrane]
GO:0031589 [cell-substrate adhesion]
GO:0031994 [insulin-like growth factor I binding]
GO:0032369 [negative regulation of lipid transport]
GO:0032587 [ruffle membrane]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034683 [integrin alphav-beta3 complex]
GO:0034684 [integrin alphav-beta5 complex]
GO:0034686 [integrin alphav-beta8 complex]
GO:0035867 [alphav-beta3 integrin-IGF-1-IGF1R complex]
GO:0035987 [endodermal cell differentiation]
GO:0038027 [apolipoprotein A-I-mediated signaling pathway]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0045335 [phagocytic vesicle]
GO:0045715 [negative regulation of low-density lipoprotein particle receptor biosynthetic process]
GO:0045785 [positive regulation of cell adhesion]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050431 [transforming growth factor beta binding]
GO:0050748 [negative regulation of lipoprotein metabolic process]
GO:0050764 [regulation of phagocytosis]
GO:0050840 [extracellular matrix binding]
GO:0050900 [leukocyte migration]
GO:0050919 [negative chemotaxis]
GO:0052066 [entry of symbiont into host cell by promotion of host phagocytosis]
GO:0070062 [extracellular exosome]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070588 [calcium ion transmembrane transport]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:1990430 [extracellular matrix protein binding]
GO:2000425 [regulation of apoptotic cell clearance]
GO:2000536 [negative regulation of entry of bacterium into host cell]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 1012 aa
112.3 kDa 		Yes 1
ITGAV-004
ENSP00000404291
ENST00000433736
P06756 [Direct mapping]
Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001618 [virus receptor activity]
GO:0001846 [opsonin binding]
GO:0001968 [fibronectin binding]
GO:0002020 [protease binding]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0005080 [protein kinase C binding]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010888 [negative regulation of lipid storage]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0016477 [cell migration]
GO:0030198 [extracellular matrix organization]
GO:0031258 [lamellipodium membrane]
GO:0031527 [filopodium membrane]
GO:0031528 [microvillus membrane]
GO:0031589 [cell-substrate adhesion]
GO:0031994 [insulin-like growth factor I binding]
GO:0032369 [negative regulation of lipid transport]
GO:0032587 [ruffle membrane]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034683 [integrin alphav-beta3 complex]
GO:0034684 [integrin alphav-beta5 complex]
GO:0034686 [integrin alphav-beta8 complex]
GO:0035867 [alphav-beta3 integrin-IGF-1-IGF1R complex]
GO:0035987 [endodermal cell differentiation]
GO:0038027 [apolipoprotein A-I-mediated signaling pathway]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0045335 [phagocytic vesicle]
GO:0045715 [negative regulation of low-density lipoprotein particle receptor biosynthetic process]
GO:0045785 [positive regulation of cell adhesion]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050431 [transforming growth factor beta binding]
GO:0050748 [negative regulation of lipoprotein metabolic process]
GO:0050764 [regulation of phagocytosis]
GO:0050840 [extracellular matrix binding]
GO:0050900 [leukocyte migration]
GO:0050919 [negative chemotaxis]
GO:0052066 [entry of symbiont into host cell by promotion of host phagocytosis]
GO:0070062 [extracellular exosome]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070588 [calcium ion transmembrane transport]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:1990430 [extracellular matrix protein binding]
GO:2000425 [regulation of apoptotic cell clearance]
GO:2000536 [negative regulation of entry of bacterium into host cell]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 1002 aa
111.1 kDa 		Yes 1
ITGAV-008
ENSP00000389442
ENST00000430709
H7BZG1 [Direct mapping]
Integrin alpha-V
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 136 aa
15.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.