Cell atlas - MNS1 - The Human Protein Atlas

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MNS1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MNS1
Gene description	Meiosis-specific nuclear structural 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles & nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Nuclear speckles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA039975
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles & nucleoplasm.

Main location

Nucleoplasm (approved), Nuclear speckles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA039975	A-431	Nucleoplasm
	HPA039975	U-2 OS	Nuclear speckles
	HPA039975	U-251 MG	Nuclear speckles
	HPA039975	U-251 MG	Cytosol

GENE INFORMATION
Gene name	MNS1 (HGNC Symbol)
Synonyms	FLJ11222, SPATA40
Description	Meiosis-specific nuclear structural 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein highly similar to the mouse meiosis-specific nuclear structural 1 protein. The mouse protein was shown to be expressed at the pachytene stage during spermatogenesis and may function as a nuclear skeletal protein to regulate nuclear morphology during meiosis. [provided by RefSeq, Oct 2008]
Chromosome	15
Cytoband	q21.3
Chromosome location (bp)	56421544 - 56465137
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138587 (version 83.38)
Entrez gene	55329
UniProt	Q8NEH6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NEH6
Antibodypedia	MNS1 antibodies

PROTEIN BROWSER

MNS1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MNS1-001 ENSP00000260453 ENST00000260453	Q8NEH6 [Direct mapping] Meiosis-specific nuclear structural protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005635 [nuclear envelope] GO:0005882 [intermediate filament] GO:0005930 [axoneme] GO:0007283 [spermatogenesis] GO:0036126 [sperm flagellum] GO:0042802 [identical protein binding] GO:0044782 [cilium organization] GO:0045724 [positive regulation of cilium assembly] GO:0051321 [meiotic cell cycle] GO:0070986 [left/right axis specification] Show all	495 aa 60.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.