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MNS1

GENERAL INFORMATION

Gene name

 MNS1

Gene description

 Meiosis-specific nuclear structural 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Group enriched (fallopian tube, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA039975 , HPA040382
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039975
HPA040382

GENE INFORMATION

Gene name

 MNS1 (HGNC Symbol)

Synonyms

 FLJ11222, SPATA40

Description

 Meiosis-specific nuclear structural 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein highly similar to the mouse meiosis-specific nuclear structural 1 protein. The mouse protein was shown to be expressed at the pachytene stage during spermatogenesis and may function as a nuclear skeletal protein to regulate nuclear morphology during meiosis. [provided by RefSeq, Oct 2008]

Chromosome

 15

Cytoband

 q21.3

Chromosome location (bp)

 56421544 - 56465137

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138587 (version 83.38)

Entrez gene

 55329

UniProt

 Q8NEH6 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8NEH6

Antibodypedia

 MNS1 antibodies

PROTEIN BROWSER
MNS1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MNS1-001
ENSP00000260453
ENST00000260453
Q8NEH6 [Direct mapping]
Meiosis-specific nuclear structural protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0005635 [nuclear envelope]
GO:0005882 [intermediate filament]
GO:0005930 [axoneme]
GO:0007283 [spermatogenesis]
GO:0036126 [sperm flagellum]
GO:0042802 [identical protein binding]
GO:0044782 [cilium organization]
GO:0045724 [positive regulation of cilium assembly]
GO:0051321 [meiotic cell cycle]
GO:0070986 [left/right axis specification]
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 495 aa
60.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.