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LEF1

GENERAL INFORMATION

Gene name

 LEF1

Gene description

 Lymphoid enhancer-binding factor 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Group enriched (MOLT-4, REH)
HPA (normal tissue):Tissue enhanced (lymph node)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in lymphoid tissue.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Cytoplasmic staining observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA002087 , CAB019405
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and endometrial cancer (favourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA002087
CAB019405

GENE INFORMATION

Gene name

 LEF1 (HGNC Symbol)

Synonyms

 TCF10, TCF1ALPHA, TCF7L3

Description

 Lymphoid enhancer-binding factor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Chromosome

 4

Cytoband

 q25

Chromosome location (bp)

 108047545 - 108168956

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138795 (version 83.38)

Entrez gene

 51176

UniProt

 Q9UJU2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UJU2

Antibodypedia

 LEF1 antibodies

PROTEIN BROWSER
LEF1-001
LEF1-003
LEF1-006
LEF1-018
LEF1-020
LEF1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LEF1-001
ENSP00000265165
ENST00000265165
Q9UJU2 [Direct mapping]
Lymphoid enhancer-binding factor 1
A0A024RDI7 [Target identity:100%; Query identity:100%]
Lymphoid enhancer-binding factor 1, isoform CRA_b
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001569 [patterning of blood vessels]
GO:0001649 [osteoblast differentiation]
GO:0001755 [neural crest cell migration]
GO:0001756 [somitogenesis]
GO:0001822 [kidney development]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001944 [vasculature development]
GO:0002040 [sprouting angiogenesis]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008301 [DNA binding, bending]
GO:0010226 [response to lithium ion]
GO:0010628 [positive regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0014070 [response to organic cyclic compound]
GO:0016055 [Wnt signaling pathway]
GO:0016202 [regulation of striated muscle tissue development]
GO:0021542 [dentate gyrus development]
GO:0021766 [hippocampus development]
GO:0021854 [hypothalamus development]
GO:0021861 [forebrain radial glial cell differentiation]
GO:0021873 [forebrain neuroblast division]
GO:0021879 [forebrain neuron differentiation]
GO:0021943 [formation of radial glial scaffolds]
GO:0022407 [regulation of cell-cell adhesion]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0030223 [neutrophil differentiation]
GO:0030284 [estrogen receptor activity]
GO:0030307 [positive regulation of cell growth]
GO:0030326 [embryonic limb morphogenesis]
GO:0030331 [estrogen receptor binding]
GO:0030335 [positive regulation of cell migration]
GO:0030509 [BMP signaling pathway]
GO:0030854 [positive regulation of granulocyte differentiation]
GO:0030879 [mammary gland development]
GO:0031100 [organ regeneration]
GO:0032696 [negative regulation of interleukin-13 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032714 [negative regulation of interleukin-5 production]
GO:0032993 [protein-DNA complex]
GO:0033153 [T cell receptor V(D)J recombination]
GO:0035326 [enhancer binding]
GO:0042100 [B cell proliferation]
GO:0042393 [histone binding]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0043586 [tongue development]
GO:0043588 [skin development]
GO:0043923 [positive regulation by host of viral transcription]
GO:0043966 [histone H3 acetylation]
GO:0043967 [histone H4 acetylation]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045063 [T-helper 1 cell differentiation]
GO:0045295 [gamma-catenin binding]
GO:0045843 [negative regulation of striated muscle tissue development]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046632 [alpha-beta T cell differentiation]
GO:0048069 [eye pigmentation]
GO:0048341 [paraxial mesoderm formation]
GO:0048468 [cell development]
GO:0048699 [generation of neurons]
GO:0048747 [muscle fiber development]
GO:0050909 [sensory perception of taste]
GO:0060021 [palate development]
GO:0060033 [anatomical structure regression]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060325 [face morphogenesis]
GO:0060326 [cell chemotaxis]
GO:0060561 [apoptotic process involved in morphogenesis]
GO:0060710 [chorio-allantoic fusion]
GO:0061153 [trachea gland development]
GO:0070016 [armadillo repeat domain binding]
GO:0070742 [C2H2 zinc finger domain binding]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071353 [cellular response to interleukin-4]
GO:0071864 [positive regulation of cell proliferation in bone marrow]
GO:0071866 [negative regulation of apoptotic process in bone marrow]
GO:0071895 [odontoblast differentiation]
GO:0071899 [negative regulation of estrogen receptor binding]
GO:0090068 [positive regulation of cell cycle process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:1902262 [apoptotic process involved in patterning of blood vessels]
Show all
 399 aa
44.2 kDa 		No 0
LEF1-003
ENSP00000422801
ENST00000515500
D6RAB1 [Direct mapping]
Lymphoid enhancer-binding factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001569 [patterning of blood vessels]
GO:0001755 [neural crest cell migration]
GO:0001756 [somitogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002040 [sprouting angiogenesis]
GO:0003682 [chromatin binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0016055 [Wnt signaling pathway]
GO:0016202 [regulation of striated muscle tissue development]
GO:0021542 [dentate gyrus development]
GO:0021854 [hypothalamus development]
GO:0021861 [forebrain radial glial cell differentiation]
GO:0021873 [forebrain neuroblast division]
GO:0021879 [forebrain neuron differentiation]
GO:0021943 [formation of radial glial scaffolds]
GO:0030326 [embryonic limb morphogenesis]
GO:0030509 [BMP signaling pathway]
GO:0030879 [mammary gland development]
GO:0042100 [B cell proliferation]
GO:0046632 [alpha-beta T cell differentiation]
GO:0048069 [eye pigmentation]
GO:0048341 [paraxial mesoderm formation]
GO:0048699 [generation of neurons]
GO:0048747 [muscle fiber development]
GO:0060325 [face morphogenesis]
GO:0060561 [apoptotic process involved in morphogenesis]
GO:0060710 [chorio-allantoic fusion]
GO:0061153 [trachea gland development]
GO:0071895 [odontoblast differentiation]
Show all
 173 aa
18.8 kDa 		No 0
LEF1-006
ENSP00000427365
ENST00000512172
D6RIV1 [Direct mapping]
Lymphoid enhancer-binding factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001569 [patterning of blood vessels]
GO:0001755 [neural crest cell migration]
GO:0001756 [somitogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002040 [sprouting angiogenesis]
GO:0003682 [chromatin binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0016055 [Wnt signaling pathway]
GO:0016202 [regulation of striated muscle tissue development]
GO:0021542 [dentate gyrus development]
GO:0021854 [hypothalamus development]
GO:0021861 [forebrain radial glial cell differentiation]
GO:0021873 [forebrain neuroblast division]
GO:0021879 [forebrain neuron differentiation]
GO:0021943 [formation of radial glial scaffolds]
GO:0030326 [embryonic limb morphogenesis]
GO:0030509 [BMP signaling pathway]
GO:0030879 [mammary gland development]
GO:0042100 [B cell proliferation]
GO:0046632 [alpha-beta T cell differentiation]
GO:0048069 [eye pigmentation]
GO:0048341 [paraxial mesoderm formation]
GO:0048699 [generation of neurons]
GO:0048747 [muscle fiber development]
GO:0060325 [face morphogenesis]
GO:0060561 [apoptotic process involved in morphogenesis]
GO:0060710 [chorio-allantoic fusion]
GO:0061153 [trachea gland development]
GO:0071895 [odontoblast differentiation]
Show all
 145 aa
15.8 kDa 		No 0
LEF1-018
ENSP00000422840
ENST00000510624
Q9UJU2 [Direct mapping]
Lymphoid enhancer-binding factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001569 [patterning of blood vessels]
GO:0001649 [osteoblast differentiation]
GO:0001755 [neural crest cell migration]
GO:0001756 [somitogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002040 [sprouting angiogenesis]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008301 [DNA binding, bending]
GO:0010628 [positive regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016055 [Wnt signaling pathway]
GO:0016202 [regulation of striated muscle tissue development]
GO:0021542 [dentate gyrus development]
GO:0021854 [hypothalamus development]
GO:0021861 [forebrain radial glial cell differentiation]
GO:0021873 [forebrain neuroblast division]
GO:0021879 [forebrain neuron differentiation]
GO:0021943 [formation of radial glial scaffolds]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030223 [neutrophil differentiation]
GO:0030284 [estrogen receptor activity]
GO:0030307 [positive regulation of cell growth]
GO:0030326 [embryonic limb morphogenesis]
GO:0030331 [estrogen receptor binding]
GO:0030335 [positive regulation of cell migration]
GO:0030509 [BMP signaling pathway]
GO:0030854 [positive regulation of granulocyte differentiation]
GO:0030879 [mammary gland development]
GO:0032696 [negative regulation of interleukin-13 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032714 [negative regulation of interleukin-5 production]
GO:0032993 [protein-DNA complex]
GO:0035326 [enhancer binding]
GO:0042100 [B cell proliferation]
GO:0042393 [histone binding]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0043923 [positive regulation by host of viral transcription]
GO:0043966 [histone H3 acetylation]
GO:0043967 [histone H4 acetylation]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045063 [T-helper 1 cell differentiation]
GO:0045295 [gamma-catenin binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046632 [alpha-beta T cell differentiation]
GO:0048069 [eye pigmentation]
GO:0048341 [paraxial mesoderm formation]
GO:0048699 [generation of neurons]
GO:0048747 [muscle fiber development]
GO:0060021 [palate development]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060325 [face morphogenesis]
GO:0060326 [cell chemotaxis]
GO:0060561 [apoptotic process involved in morphogenesis]
GO:0060710 [chorio-allantoic fusion]
GO:0061153 [trachea gland development]
GO:0070016 [armadillo repeat domain binding]
GO:0070742 [C2H2 zinc finger domain binding]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071353 [cellular response to interleukin-4]
GO:0071864 [positive regulation of cell proliferation in bone marrow]
GO:0071866 [negative regulation of apoptotic process in bone marrow]
GO:0071895 [odontoblast differentiation]
GO:0071899 [negative regulation of estrogen receptor binding]
GO:0090068 [positive regulation of cell cycle process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 303 aa
34.1 kDa 		No 0
LEF1-020
ENSP00000406176
ENST00000438313
Q9UJU2 [Direct mapping]
Lymphoid enhancer-binding factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001569 [patterning of blood vessels]
GO:0001649 [osteoblast differentiation]
GO:0001755 [neural crest cell migration]
GO:0001756 [somitogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002040 [sprouting angiogenesis]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008301 [DNA binding, bending]
GO:0010628 [positive regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016055 [Wnt signaling pathway]
GO:0016202 [regulation of striated muscle tissue development]
GO:0021542 [dentate gyrus development]
GO:0021854 [hypothalamus development]
GO:0021861 [forebrain radial glial cell differentiation]
GO:0021873 [forebrain neuroblast division]
GO:0021879 [forebrain neuron differentiation]
GO:0021943 [formation of radial glial scaffolds]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030223 [neutrophil differentiation]
GO:0030284 [estrogen receptor activity]
GO:0030307 [positive regulation of cell growth]
GO:0030326 [embryonic limb morphogenesis]
GO:0030331 [estrogen receptor binding]
GO:0030335 [positive regulation of cell migration]
GO:0030509 [BMP signaling pathway]
GO:0030854 [positive regulation of granulocyte differentiation]
GO:0030879 [mammary gland development]
GO:0032696 [negative regulation of interleukin-13 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032714 [negative regulation of interleukin-5 production]
GO:0032993 [protein-DNA complex]
GO:0035326 [enhancer binding]
GO:0042100 [B cell proliferation]
GO:0042393 [histone binding]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0043923 [positive regulation by host of viral transcription]
GO:0043966 [histone H3 acetylation]
GO:0043967 [histone H4 acetylation]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045063 [T-helper 1 cell differentiation]
GO:0045295 [gamma-catenin binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046632 [alpha-beta T cell differentiation]
GO:0048069 [eye pigmentation]
GO:0048341 [paraxial mesoderm formation]
GO:0048699 [generation of neurons]
GO:0048747 [muscle fiber development]
GO:0060021 [palate development]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060325 [face morphogenesis]
GO:0060326 [cell chemotaxis]
GO:0060561 [apoptotic process involved in morphogenesis]
GO:0060710 [chorio-allantoic fusion]
GO:0061153 [trachea gland development]
GO:0070016 [armadillo repeat domain binding]
GO:0070742 [C2H2 zinc finger domain binding]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071353 [cellular response to interleukin-4]
GO:0071864 [positive regulation of cell proliferation in bone marrow]
GO:0071866 [negative regulation of apoptotic process in bone marrow]
GO:0071895 [odontoblast differentiation]
GO:0071899 [negative regulation of estrogen receptor binding]
GO:0090068 [positive regulation of cell cycle process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 371 aa
41.2 kDa 		No 0
LEF1-201
ENSP00000369284
ENST00000379951
Q9UJU2 [Direct mapping]
Lymphoid enhancer-binding factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001569 [patterning of blood vessels]
GO:0001649 [osteoblast differentiation]
GO:0001755 [neural crest cell migration]
GO:0001756 [somitogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002040 [sprouting angiogenesis]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008301 [DNA binding, bending]
GO:0010628 [positive regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016055 [Wnt signaling pathway]
GO:0016202 [regulation of striated muscle tissue development]
GO:0021542 [dentate gyrus development]
GO:0021854 [hypothalamus development]
GO:0021861 [forebrain radial glial cell differentiation]
GO:0021873 [forebrain neuroblast division]
GO:0021879 [forebrain neuron differentiation]
GO:0021943 [formation of radial glial scaffolds]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030223 [neutrophil differentiation]
GO:0030284 [estrogen receptor activity]
GO:0030307 [positive regulation of cell growth]
GO:0030326 [embryonic limb morphogenesis]
GO:0030331 [estrogen receptor binding]
GO:0030335 [positive regulation of cell migration]
GO:0030509 [BMP signaling pathway]
GO:0030854 [positive regulation of granulocyte differentiation]
GO:0030879 [mammary gland development]
GO:0032696 [negative regulation of interleukin-13 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032714 [negative regulation of interleukin-5 production]
GO:0032993 [protein-DNA complex]
GO:0035326 [enhancer binding]
GO:0042100 [B cell proliferation]
GO:0042393 [histone binding]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0043923 [positive regulation by host of viral transcription]
GO:0043966 [histone H3 acetylation]
GO:0043967 [histone H4 acetylation]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045063 [T-helper 1 cell differentiation]
GO:0045295 [gamma-catenin binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046632 [alpha-beta T cell differentiation]
GO:0048069 [eye pigmentation]
GO:0048341 [paraxial mesoderm formation]
GO:0048699 [generation of neurons]
GO:0048747 [muscle fiber development]
GO:0060021 [palate development]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060325 [face morphogenesis]
GO:0060326 [cell chemotaxis]
GO:0060561 [apoptotic process involved in morphogenesis]
GO:0060710 [chorio-allantoic fusion]
GO:0061153 [trachea gland development]
GO:0070016 [armadillo repeat domain binding]
GO:0070742 [C2H2 zinc finger domain binding]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071353 [cellular response to interleukin-4]
GO:0071864 [positive regulation of cell proliferation in bone marrow]
GO:0071866 [negative regulation of apoptotic process in bone marrow]
GO:0071895 [odontoblast differentiation]
GO:0071899 [negative regulation of estrogen receptor binding]
GO:0090068 [positive regulation of cell cycle process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 386 aa
42.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.