Expression of KIF21A in cancer - Summary

GENERAL INFORMATION
Gene name	KIF21A
Gene description	Kinesin family member 21A
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (SH-SY5Y)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a subset of cells including neuronal cells, respiratory epithelia and cells in seminiferous ducts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA058432 , CAB022079
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA058432	CAB022079

GENE INFORMATION
Gene name	KIF21A (HGNC Symbol)
Synonyms	FEOM1, FLJ20052
Description	Kinesin family member 21A (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
Chromosome	12
Cytoband	q12
Chromosome location (bp)	39293228 - 39443390
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139116 (version 83.38)
Entrez gene	55605
UniProt	Q7Z4S6 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z4S6
Antibodypedia	KIF21A antibodies

PROTEIN BROWSER

KIF21A-001	KIF21A-002	KIF21A-003	KIF21A-004	KIF21A-005	KIF21A-008	KIF21A-009	KIF21A-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KIF21A-001 ENSP00000354851 ENST00000361961	Q7Z4S6 [Direct mapping] Kinesin-like protein KIF21A Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003777 [microtubule motor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005871 [kinesin complex] GO:0005874 [microtubule] GO:0007018 [microtubule-based movement] GO:0008017 [microtubule binding] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] Show all	1661 aa 185.5 kDa	No	0
KIF21A-002 ENSP00000445606 ENST00000544797	Q7Z4S6 [Direct mapping] Kinesin-like protein KIF21A Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003777 [microtubule motor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005871 [kinesin complex] GO:0005874 [microtubule] GO:0007018 [microtubule-based movement] GO:0008017 [microtubule binding] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] Show all	1637 aa 182.9 kDa	No	0
KIF21A-003 ENSP00000354878 ENST00000361418	Q7Z4S6 [Direct mapping] Kinesin-like protein KIF21A Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003777 [microtubule motor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005871 [kinesin complex] GO:0005874 [microtubule] GO:0007018 [microtubule-based movement] GO:0008017 [microtubule binding] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] Show all	1674 aa 187.2 kDa	No	0
KIF21A-004 ENSP00000447765 ENST00000552961	H0YHT2 [Direct mapping] Kinesin-like protein KIF21A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003777 [microtubule motor activity] GO:0005515 [protein binding] GO:0005871 [kinesin complex] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] Show all	975 aa 108.7 kDa	No	0
KIF21A-005 ENSP00000448792 ENST00000551264	H0YI78 [Direct mapping] Kinesin-like protein KIF21A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003777 [microtubule motor activity] GO:0005515 [protein binding] GO:0005871 [kinesin complex] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] Show all	655 aa 71.5 kDa	No	0
KIF21A-008 ENSP00000438075 ENST00000541463	Q7Z4S6 [Direct mapping] Kinesin-like protein KIF21A Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003777 [microtubule motor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005871 [kinesin complex] GO:0005874 [microtubule] GO:0007018 [microtubule-based movement] GO:0008017 [microtubule binding] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] Show all	1621 aa 180.7 kDa	No	0
KIF21A-009 ENSP00000449700 ENST00000552908	H0YIM7 [Direct mapping] Kinesin-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003777 [microtubule motor activity] GO:0005524 [ATP binding] GO:0005871 [kinesin complex] GO:0005874 [microtubule] GO:0007018 [microtubule-based movement] GO:0008017 [microtubule binding] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] Show all	290 aa 32.5 kDa	No	0
KIF21A-013 ENSP00000447070 ENST00000551066	H0YHG9 [Direct mapping] Kinesin-like protein KIF21A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003777 [microtubule motor activity] GO:0005871 [kinesin complex] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] Show all	138 aa 15.3 kDa	No	0