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KIF21A

GENERAL INFORMATION

Gene name

 KIF21A

Gene description

 Kinesin family member 21A

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a subset of cells including neuronal cells, respiratory epithelia and cells in seminiferous ducts.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA058432 , CAB022079
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Rectum

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 KIF21A (HGNC Symbol)

Synonyms

 FEOM1, FLJ20052

Description

 Kinesin family member 21A (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]

Chromosome

 12

Cytoband

 q12

Chromosome location (bp)

 39293228 - 39443390

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139116 (version 83.38)

Entrez gene

 55605

UniProt

 Q7Z4S6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z4S6

Antibodypedia

 KIF21A antibodies

PROTEIN BROWSER
KIF21A-001
KIF21A-002
KIF21A-003
KIF21A-004
KIF21A-005
KIF21A-008
KIF21A-009
KIF21A-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KIF21A-001
ENSP00000354851
ENST00000361961
Q7Z4S6 [Direct mapping]
Kinesin-like protein KIF21A
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 1661 aa
185.5 kDa 		No 0
KIF21A-002
ENSP00000445606
ENST00000544797
Q7Z4S6 [Direct mapping]
Kinesin-like protein KIF21A
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 1637 aa
182.9 kDa 		No 0
KIF21A-003
ENSP00000354878
ENST00000361418
Q7Z4S6 [Direct mapping]
Kinesin-like protein KIF21A
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 1674 aa
187.2 kDa 		No 0
KIF21A-004
ENSP00000447765
ENST00000552961
H0YHT2 [Direct mapping]
Kinesin-like protein KIF21A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005871 [kinesin complex]
GO:0007018 [microtubule-based movement]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 975 aa
108.7 kDa 		No 0
KIF21A-005
ENSP00000448792
ENST00000551264
H0YI78 [Direct mapping]
Kinesin-like protein KIF21A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005871 [kinesin complex]
GO:0007018 [microtubule-based movement]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 655 aa
71.5 kDa 		No 0
KIF21A-008
ENSP00000438075
ENST00000541463
Q7Z4S6 [Direct mapping]
Kinesin-like protein KIF21A
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 1621 aa
180.7 kDa 		No 0
KIF21A-009
ENSP00000449700
ENST00000552908
H0YIM7 [Direct mapping]
Kinesin-like protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 290 aa
32.5 kDa 		No 0
KIF21A-013
ENSP00000447070
ENST00000551066
H0YHG9 [Direct mapping]
Kinesin-like protein KIF21A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005871 [kinesin complex]
GO:0007018 [microtubule-based movement]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 138 aa
15.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.