Expression of SLC38A4 in cancer - Summary - The Human Protein Atlas

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SLC38A4

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	SLC38A4
Gene description	Solute carrier family 38, member 4
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Group enriched (LHCN-M2, RH-30, RT4)
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	SLC38A4 (HGNC Symbol)
Synonyms	ATA3, NAT3, PAAT
Description	Solute carrier family 38, member 4 (HGNC Symbol)
Entrez gene summary	SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids. The transport of cationic amino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral amino acids is Na(+) and pH dependent (Hatanaka et al., 2001 [PubMed 11342143]).[supplied by OMIM, Mar 2008]
Chromosome	12
Cytoband	q13.11
Chromosome location (bp)	46764761 - 46832408
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139209 (version 83.38)
Entrez gene	55089
UniProt	Q969I6 (UniProt - Evidence at protein level)
neXtProt	NX_Q969I6
Antibodypedia	SLC38A4 antibodies

PROTEIN BROWSER

SLC38A4-001	SLC38A4-002	SLC38A4-003	SLC38A4-004	SLC38A4-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC38A4-001 ENSP00000389843 ENST00000447411	Q969I6 [Direct mapping] Sodium-coupled neutral amino acid transporter 4 A0A024R0X7 [Target identity:100%; Query identity:100%] Solute carrier family 38, member 4, isoform CRA_c Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0006865 [amino acid transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0015293 [symporter activity] GO:0055085 [transmembrane transport] Show all	547 aa 60.8 kDa	No	>9
SLC38A4-002 ENSP00000266579 ENST00000266579	Q969I6 [Direct mapping] Sodium-coupled neutral amino acid transporter 4 A0A024R0X7 [Target identity:100%; Query identity:100%] Solute carrier family 38, member 4, isoform CRA_c Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0006865 [amino acid transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0015293 [symporter activity] GO:0055085 [transmembrane transport] Show all	547 aa 60.8 kDa	No	>9
SLC38A4-003 ENSP00000448543 ENST00000546940	F8VRD9 [Direct mapping] Sodium-coupled neutral amino acid transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0003333 [amino acid transmembrane transport] GO:0005887 [integral component of plasma membrane] GO:0015171 [amino acid transmembrane transporter activity] Show all	192 aa 20.7 kDa	No	3
SLC38A4-004 ENSP00000450071 ENST00000547477	F8VQY9 [Direct mapping] Sodium-coupled neutral amino acid transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0003333 [amino acid transmembrane transport] GO:0005887 [integral component of plasma membrane] GO:0015171 [amino acid transmembrane transporter activity] Show all	219 aa 23.8 kDa	No	5
SLC38A4-005 ENSP00000448186 ENST00000550670	H0YHZ8 [Direct mapping] Sodium-coupled neutral amino acid transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0003333 [amino acid transmembrane transport] GO:0005887 [integral component of plasma membrane] GO:0015171 [amino acid transmembrane transporter activity] Show all	141 aa 15.9 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.