Tissue expression of SLC38A4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLC38A4
Gene description	Solute carrier family 38, member 4
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (liver)
GTEx:	Tissue enriched (liver)
FANTOM5:	Tissue enriched (liver)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)

GENE INFORMATION
Gene name	SLC38A4 (HGNC Symbol)
Synonyms	ATA3, NAT3, PAAT
Description	Solute carrier family 38, member 4 (HGNC Symbol)
Entrez gene summary	SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids. The transport of cationic amino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral amino acids is Na(+) and pH dependent (Hatanaka et al., 2001 [PubMed 11342143]).[supplied by OMIM, Mar 2008]
Chromosome	12
Cytoband	q13.11
Chromosome location (bp)	46764761 - 46832408
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139209 (version 83.38)
Entrez gene	55089
UniProt	Q969I6 (UniProt - Evidence at protein level)
neXtProt	NX_Q969I6
Antibodypedia	SLC38A4 antibodies

PROTEIN BROWSER

SLC38A4-001	SLC38A4-002	SLC38A4-003	SLC38A4-004	SLC38A4-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC38A4-001 ENSP00000389843 ENST00000447411	Q969I6 [Direct mapping] Sodium-coupled neutral amino acid transporter 4 A0A024R0X7 [Target identity:100%; Query identity:100%] Solute carrier family 38, member 4, isoform CRA_c Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0006865 [amino acid transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0015293 [symporter activity] GO:0055085 [transmembrane transport] Show all	547 aa 60.8 kDa	No	>9
SLC38A4-002 ENSP00000266579 ENST00000266579	Q969I6 [Direct mapping] Sodium-coupled neutral amino acid transporter 4 A0A024R0X7 [Target identity:100%; Query identity:100%] Solute carrier family 38, member 4, isoform CRA_c Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0006865 [amino acid transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0015293 [symporter activity] GO:0055085 [transmembrane transport] Show all	547 aa 60.8 kDa	No	>9
SLC38A4-003 ENSP00000448543 ENST00000546940	F8VRD9 [Direct mapping] Sodium-coupled neutral amino acid transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0003333 [amino acid transmembrane transport] GO:0005887 [integral component of plasma membrane] GO:0015171 [amino acid transmembrane transporter activity] Show all	192 aa 20.7 kDa	No	3
SLC38A4-004 ENSP00000450071 ENST00000547477	F8VQY9 [Direct mapping] Sodium-coupled neutral amino acid transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0003333 [amino acid transmembrane transport] GO:0005887 [integral component of plasma membrane] GO:0015171 [amino acid transmembrane transporter activity] Show all	219 aa 23.8 kDa	No	5
SLC38A4-005 ENSP00000448186 ENST00000550670	H0YHZ8 [Direct mapping] Sodium-coupled neutral amino acid transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0003333 [amino acid transmembrane transport] GO:0005887 [integral component of plasma membrane] GO:0015171 [amino acid transmembrane transporter activity] Show all	141 aa 15.9 kDa	No	1