Expression of DPEP3 in cancer - Summary - The Human Protein Atlas

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DPEP3

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DPEP3
Gene description	Dipeptidase 3
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (melanoma, ovarian cancer, testis cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA031870 , HPA058607
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (melanoma, ovarian cancer, testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031870	HPA058607

GENE INFORMATION
Gene name	DPEP3
Synonyms
Description	Dipeptidase 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a membrane-bound glycoprotein from the family of dipeptidases involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family. Alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	67975663 - 67980829
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141096 (version 83.38)
Entrez gene	64180
UniProt	Q9H4B8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H4B8
Antibodypedia	DPEP3 antibodies

PROTEIN BROWSER

DPEP3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DPEP3-001 ENSP00000268793 ENST00000268793	Q9H4B8 [Direct mapping] Dipeptidase 3 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0007140 [male meiosis] GO:0008233 [peptidase activity] GO:0008235 [metalloexopeptidase activity] GO:0008239 [dipeptidyl-peptidase activity] GO:0016020 [membrane] GO:0016805 [dipeptidase activity] GO:0031225 [anchored component of membrane] GO:0046872 [metal ion binding] Show all	513 aa 56.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.