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MAPK4

GENERAL INFORMATION

Gene name

 MAPK4

Gene description

 Mitogen-activated protein kinase 4

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (glioma, melanoma)
HPA (cell line):Cell line enhanced (SCLC-21H, SH-SY5Y)
HPA (normal tissue):Tissue enhanced (adrenal gland, cerebral cortex, parathyroid gland)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (glioma, melanoma)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 MAPK4 (HGNC Symbol)

Synonyms

 Erk3-related, Erk4, PRKM4

Description

 Mitogen-activated protein kinase 4 (HGNC Symbol)

Entrez gene summary

 Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Chromosome

 18

Cytoband

Chromosome location (bp)

 50560078 - 50731824

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141639 (version 83.38)

Entrez gene

 5596

UniProt

 P31152 (UniProt - Evidence at protein level)

neXtProt

 NX_P31152

Antibodypedia

 MAPK4 antibodies

PROTEIN BROWSER
MAPK4-001
MAPK4-002
MAPK4-003
MAPK4-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAPK4-001
ENSP00000383234
ENST00000400384
P31152 [Direct mapping]
Mitogen-activated protein kinase 4
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
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GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0019901 [protein kinase binding]
GO:0042803 [protein homodimerization activity]
GO:0046982 [protein heterodimerization activity]
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 587 aa
65.9 kDa 		No 0
MAPK4-002
ENSP00000466233
ENST00000592595
K7ELV1 [Direct mapping]
Mitogen-activated protein kinase 4
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
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 233 aa
26.2 kDa 		No 0
MAPK4-003
ENSP00000465661
ENST00000588540
K7EN18 [Direct mapping]
Mitogen-activated protein kinase 4
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Predicted intracellular proteins
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GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
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 281 aa
31.1 kDa 		No 0
MAPK4-005
ENSP00000439231
ENST00000540640
B4DEW2 [Direct mapping]
Mitogen-activated protein kinase 4; cDNA FLJ50121, highly similar to Homo sapiens mitogen-activated protein kinase 4 (MAPK4), mRNA
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Predicted intracellular proteins
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GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
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 376 aa
42.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.