Tissue expression of MAPK4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MAPK4
Gene description	Mitogen-activated protein kinase 4
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (adrenal gland, cerebral cortex, parathyroid gland)
GTEx:	Tissue enhanced (caudate)
FANTOM5:	Tissue enhanced (caudate, cerebellum)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adrenal gland, cerebral cortex, parathyroid gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate, cerebellum)

GENE INFORMATION
Gene name	MAPK4 (HGNC Symbol)
Synonyms	Erk3-related, Erk4, PRKM4
Description	Mitogen-activated protein kinase 4 (HGNC Symbol)
Entrez gene summary	Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Chromosome	18
Cytoband
Chromosome location (bp)	50560078 - 50731824
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141639 (version 83.38)
Entrez gene	5596
UniProt	P31152 (UniProt - Evidence at protein level)
neXtProt	NX_P31152
Antibodypedia	MAPK4 antibodies

PROTEIN BROWSER

MAPK4-001	MAPK4-002	MAPK4-003	MAPK4-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAPK4-001 ENSP00000383234 ENST00000400384	P31152 [Direct mapping] Mitogen-activated protein kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004707 [MAP kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0019901 [protein kinase binding] GO:0042803 [protein homodimerization activity] GO:0046982 [protein heterodimerization activity] Show all	587 aa 65.9 kDa	No	0
MAPK4-002 ENSP00000466233 ENST00000592595	K7ELV1 [Direct mapping] Mitogen-activated protein kinase 4 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0004707 [MAP kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] Show all	233 aa 26.2 kDa	No	0
MAPK4-003 ENSP00000465661 ENST00000588540	K7EN18 [Direct mapping] Mitogen-activated protein kinase 4 Show all	Predicted intracellular proteins Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0004707 [MAP kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] Show all	281 aa 31.1 kDa	No	0
MAPK4-005 ENSP00000439231 ENST00000540640	B4DEW2 [Direct mapping] Mitogen-activated protein kinase 4; cDNA FLJ50121, highly similar to Homo sapiens mitogen-activated protein kinase 4 (MAPK4), mRNA Show all	Predicted intracellular proteins Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0004707 [MAP kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] Show all	376 aa 42.1 kDa	No	0