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The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000187 [activation of MAPK activity] GO:0000302 [response to reactive oxygen species] GO:0000303 [response to superoxide] GO:0001541 [ovarian follicle development] GO:0001819 [positive regulation of cytokine production] GO:0001890 [placenta development] GO:0001895 [retina homeostasis] GO:0001975 [response to amphetamine] GO:0002262 [myeloid cell homeostasis] GO:0002576 [platelet degranulation] GO:0004784 [superoxide dismutase activity] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005758 [mitochondrial intermembrane space] GO:0005759 [mitochondrial matrix] GO:0005764 [lysosome] GO:0005777 [peroxisome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006749 [glutathione metabolic process] GO:0006801 [superoxide metabolic process] GO:0006879 [cellular iron ion homeostasis] GO:0006979 [response to oxidative stress] GO:0007283 [spermatogenesis] GO:0007566 [embryo implantation] GO:0007568 [aging] GO:0007569 [cell aging] GO:0007596 [blood coagulation] GO:0007605 [sensory perception of sound] GO:0007626 [locomotory behavior] GO:0008089 [anterograde axon cargo transport] GO:0008090 [retrograde axon cargo transport] GO:0008217 [regulation of blood pressure] GO:0008270 [zinc ion binding] GO:0009408 [response to heat] GO:0010033 [response to organic substance] GO:0019226 [transmission of nerve impulse] GO:0019430 [removal of superoxide radicals] GO:0019899 [enzyme binding] GO:0030141 [secretory granule] GO:0030168 [platelet activation] GO:0030346 [protein phosphatase 2B binding] GO:0031012 [extracellular matrix] GO:0031045 [dense core granule] GO:0031410 [cytoplasmic vesicle] GO:0031667 [response to nutrient levels] GO:0032287 [peripheral nervous system myelin maintenance] GO:0032839 [dendrite cytoplasm] GO:0032930 [positive regulation of superoxide anion generation] GO:0033081 [regulation of T cell differentiation in thymus] GO:0034465 [response to carbon monoxide] GO:0034599 [cellular response to oxidative stress] GO:0035865 [cellular response to potassium ion] GO:0040014 [regulation of multicellular organism growth] GO:0042493 [response to drug] GO:0042542 [response to hydrogen peroxide] GO:0042554 [superoxide anion generation] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043085 [positive regulation of catalytic activity] GO:0043087 [regulation of GTPase activity] GO:0043209 [myelin sheath] GO:0043234 [protein complex] GO:0043524 [negative regulation of neuron apoptotic process] GO:0045471 [response to ethanol] GO:0045541 [negative regulation of cholesterol biosynthetic process] GO:0045859 [regulation of protein kinase activity] GO:0046620 [regulation of organ growth] GO:0046677 [response to antibiotic] GO:0046688 [response to copper ion] GO:0046716 [muscle cell cellular homeostasis] GO:0046872 [metal ion binding] GO:0048365 [Rac GTPase binding] GO:0048538 [thymus development] GO:0048678 [response to axon injury] GO:0050665 [hydrogen peroxide biosynthetic process] GO:0051087 [chaperone binding] GO:0051881 [regulation of mitochondrial membrane potential] GO:0055114 [oxidation-reduction process] GO:0060047 [heart contraction] GO:0060052 [neurofilament cytoskeleton organization] GO:0060087 [relaxation of vascular smooth muscle] GO:0060088 [auditory receptor cell stereocilium organization] GO:0070062 [extracellular exosome] GO:0071276 [cellular response to cadmium ion] GO:0071318 [cellular response to ATP] GO:0072593 [reactive oxygen species metabolic process] GO:0097332 [response to antipsychotic drug] GO:1902177 [positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]