Cell atlas - SCYL1 - The Human Protein Atlas

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SCYL1

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	SCYL1
Gene description	SCY1-like, kinase-like 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Mouse	Localized to the Plasma membrane in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA015015
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA015015	A-431	Cytosol
	HPA015015	U-2 OS	No staining
	HPA015015	U-251 MG	Cytosol

MOUSE CELLS

Main location

Plasma membrane

Mouse gene

ENSMUSG00000024941 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA015015	NIH 3T3	Plasma membrane

GENE INFORMATION
Gene name	SCYL1 (HGNC Symbol)
Synonyms	GKLP, HT019, MGC78454, NKTL, NTKL, P105, TAPK, TEIF, TRAP
Description	SCY1-like, kinase-like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	65525077 - 65538704
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142186 (version 83.38)
Entrez gene	57410
UniProt	Q96KG9 (UniProt - Evidence at protein level)
neXtProt	NX_Q96KG9
Antibodypedia	SCYL1 antibodies

PROTEIN BROWSER

SCYL1-001	SCYL1-002	SCYL1-003	SCYL1-005	SCYL1-006	SCYL1-013	SCYL1-014	SCYL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCYL1-001 ENSP00000270176 ENST00000270176	Q96KG9 [Direct mapping] N-terminal kinase-like protein Show all	Enzymes Kinases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0005794 [Golgi apparatus] GO:0005801 [cis-Golgi network] GO:0005815 [microtubule organizing center] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030126 [COPI vesicle coat] Show all	808 aa 89.6 kDa	No	0
SCYL1-002 ENSP00000408192 ENST00000420247	Q96KG9 [Direct mapping] N-terminal kinase-like protein Show all	Enzymes Kinases MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005488 [binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0005794 [Golgi apparatus] GO:0005801 [cis-Golgi network] GO:0005815 [microtubule organizing center] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030126 [COPI vesicle coat] Show all	791 aa 88.1 kDa	No	0
SCYL1-003 ENSP00000436993 ENST00000527009	E9PPN3 [Direct mapping] N-terminal kinase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005488 [binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] Show all	665 aa 73.7 kDa	No	0
SCYL1-005 ENSP00000432175 ENST00000524944	E9PS17 [Direct mapping] N-terminal kinase-like protein Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005488 [binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] Show all	775 aa 85.7 kDa	No	0
SCYL1-006 ENSP00000437254 ENST00000533862	Q96KG9 [Direct mapping] N-terminal kinase-like protein Show all	Enzymes Kinases MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005488 [binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0005794 [Golgi apparatus] GO:0005801 [cis-Golgi network] GO:0005815 [microtubule organizing center] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030126 [COPI vesicle coat] Show all	787 aa 86.4 kDa	No	0
SCYL1-013 ENSP00000433604 ENST00000528545	H0YDH0 [Direct mapping] N-terminal kinase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		280 aa 30.6 kDa	No	0
SCYL1-014 ENSP00000431635 ENST00000525364	E9PK59 [Direct mapping] N-terminal kinase-like protein Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005488 [binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] Show all	780 aa 86.2 kDa	No	0
SCYL1-201 ENSP00000279270 ENST00000279270	A0A0A0MQX4 [Direct mapping] N-terminal kinase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	270 aa 29.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.