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SCYL1

GENERAL INFORMATION

Gene name

 SCYL1

Gene description

 SCY1-like, kinase-like 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Expression in several tissues including smooth muscle and endothelial cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining in cells/structures not annotated, view images. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA015015
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA015015

GENE INFORMATION

Gene name

 SCYL1 (HGNC Symbol)

Synonyms

 GKLP, HT019, MGC78454, NKTL, NTKL, P105, TAPK, TEIF, TRAP

Description

 SCY1-like, kinase-like 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 65525077 - 65538704

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142186 (version 83.38)

Entrez gene

 57410

UniProt

 Q96KG9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96KG9

Antibodypedia

 SCYL1 antibodies

PROTEIN BROWSER
SCYL1-001
SCYL1-002
SCYL1-003
SCYL1-005
SCYL1-006
SCYL1-013
SCYL1-014
SCYL1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SCYL1-001
ENSP00000270176
ENST00000270176
Q96KG9 [Direct mapping]
N-terminal kinase-like protein
Show all
Enzymes
   Kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005794 [Golgi apparatus]
GO:0005801 [cis-Golgi network]
GO:0005815 [microtubule organizing center]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030126 [COPI vesicle coat]
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 808 aa
89.6 kDa 		No 0
SCYL1-002
ENSP00000408192
ENST00000420247
Q96KG9 [Direct mapping]
N-terminal kinase-like protein
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Enzymes
   Kinases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005488 [binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005794 [Golgi apparatus]
GO:0005801 [cis-Golgi network]
GO:0005815 [microtubule organizing center]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030126 [COPI vesicle coat]
Show all
 791 aa
88.1 kDa 		No 0
SCYL1-003
ENSP00000436993
ENST00000527009
E9PPN3 [Direct mapping]
N-terminal kinase-like protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005488 [binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
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 665 aa
73.7 kDa 		No 0
SCYL1-005
ENSP00000432175
ENST00000524944
E9PS17 [Direct mapping]
N-terminal kinase-like protein
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005488 [binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
Show all
 775 aa
85.7 kDa 		No 0
SCYL1-006
ENSP00000437254
ENST00000533862
Q96KG9 [Direct mapping]
N-terminal kinase-like protein
Show all
Enzymes
   Kinases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005488 [binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005794 [Golgi apparatus]
GO:0005801 [cis-Golgi network]
GO:0005815 [microtubule organizing center]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030126 [COPI vesicle coat]
Show all
 787 aa
86.4 kDa 		No 0
SCYL1-013
ENSP00000433604
ENST00000528545
H0YDH0 [Direct mapping]
N-terminal kinase-like protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 280 aa
30.6 kDa 		No 0
SCYL1-014
ENSP00000431635
ENST00000525364
E9PK59 [Direct mapping]
N-terminal kinase-like protein
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005488 [binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
Show all
 780 aa
86.2 kDa 		No 0
SCYL1-201
ENSP00000279270
ENST00000279270
A0A0A0MQX4 [Direct mapping]
N-terminal kinase-like protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
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 270 aa
29.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.