Cell atlas - ADAMTS10 - The Human Protein Atlas

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ADAMTS10

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	ADAMTS10
Gene description	ADAM metallopeptidase with thrombospondin type 1 motif, 10
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (NB-4, REH)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA040223
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (NB-4, REH) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040223	HeLa	Cytosol
	HPA040223	U-2 OS	Cytosol
	HPA040223	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ADAMTS10 (HGNC Symbol)
Synonyms	ADAM-TS10
Description	ADAM metallopeptidase with thrombospondin type 1 motif, 10 (HGNC Symbol)
Entrez gene summary	This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	8580242 - 8610735
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142303 (version 83.38)
Entrez gene	81794
UniProt	Q9H324 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H324
Antibodypedia	ADAMTS10 antibodies

PROTEIN BROWSER

ADAMTS10-001	ADAMTS10-003	ADAMTS10-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAMTS10-001 ENSP00000471851 ENST00000597188	A0A0A0MQW6 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 10 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] Show all	1103 aa 120.9 kDa	Yes	0
ADAMTS10-003 ENSP00000470501 ENST00000595838	Q9H324 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 10 Show all	Enzymes Peptidases Metallopeptidases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Show all	GO:0001527 [microfibril] GO:0003674 [molecular_function] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0008150 [biological_process] GO:0008233 [peptidase activity] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] Show all	590 aa 62.5 kDa	No	0
ADAMTS10-201 ENSP00000270328 ENST00000270328	A0A0A0MQW6 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 10 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] Show all	1103 aa 120.9 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.