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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

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Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

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Antibodies

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ADAMTS10
  • TISSUE

  • CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ADAMTS10

Gene description

ADAM metallopeptidase with thrombospondin type 1 motif, 10

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Uncertain based on 1 antibody.
HPA040223
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

ADAMTS10 (HGNC Symbol)

Synonyms

ADAM-TS10

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 10 (HGNC Symbol)

Entrez gene summary

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.2

Chromosome location (bp)

8580242 - 8610735

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142303 (version 83.38)

Entrez gene

81794

UniProt

Q9H324 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H324

Antibodypedia

ADAMTS10 antibodies

PROTEIN BROWSER

ADAMTS10-001
ADAMTS10-003
ADAMTS10-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAMTS10-001
ENSP00000471851
ENST00000597188
A0A0A0MQW6 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 10
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005578 [proteinaceous extracellular matrix]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
Show all
1103 aa
120.9 kDa
Yes 0
ADAMTS10-003
ENSP00000470501
ENST00000595838
Q9H324 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 10
Show all
Enzymes
   Peptidases
   Metallopeptidases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0001527 [microfibril]
GO:0003674 [molecular_function]
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0006508 [proteolysis]
GO:0008150 [biological_process]
GO:0008233 [peptidase activity]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
Show all
590 aa
62.5 kDa
No 0
ADAMTS10-201
ENSP00000270328
ENST00000270328
A0A0A0MQW6 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 10
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005578 [proteinaceous extracellular matrix]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
Show all
1103 aa
120.9 kDa
Yes 0

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