Expression of ADAMTS10 in cancer - Summary - The Human Protein Atlas

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ADAMTS10

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADAMTS10
Gene description	ADAM metallopeptidase with thrombospondin type 1 motif, 10
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (NB-4, REH)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. HPA040223
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040223

GENE INFORMATION
Gene name	ADAMTS10 (HGNC Symbol)
Synonyms	ADAM-TS10
Description	ADAM metallopeptidase with thrombospondin type 1 motif, 10 (HGNC Symbol)
Entrez gene summary	This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	8580242 - 8610735
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142303 (version 83.38)
Entrez gene	81794
UniProt	Q9H324 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H324
Antibodypedia	ADAMTS10 antibodies

PROTEIN BROWSER

ADAMTS10-001	ADAMTS10-003	ADAMTS10-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAMTS10-001 ENSP00000471851 ENST00000597188	A0A0A0MQW6 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 10 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] Show all	1103 aa 120.9 kDa	Yes	0
ADAMTS10-003 ENSP00000470501 ENST00000595838	Q9H324 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 10 Show all	Enzymes Peptidases Metallopeptidases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Show all	GO:0001527 [microfibril] GO:0003674 [molecular_function] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0008150 [biological_process] GO:0008233 [peptidase activity] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] Show all	590 aa 62.5 kDa	No	0
ADAMTS10-201 ENSP00000270328 ENST00000270328	A0A0A0MQW6 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 10 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] Show all	1103 aa 120.9 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.