Cell atlas - PLK4 - The Human Protein Atlas

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PLK4

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Cytosol

Human cell
	Centrosome
	Cytosol

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GENERAL INFORMATION
Gene name	PLK4
Gene description	Polo-like kinase 4
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & centrosome.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Centrosome (supported), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA017327
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & centrosome.

Main location

Centrosome (supported), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA017327	A-431	Centrosome
	HPA017327	A-431	Cytosol	Intensity
	HPA017327	U-2 OS	No staining

GENE INFORMATION
Gene name	PLK4 (HGNC Symbol)
Synonyms	Sak, STK18
Description	Polo-like kinase 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Chromosome	4
Cytoband	q28.1
Chromosome location (bp)	127880861 - 127899195
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142731 (version 83.38)
Entrez gene	10733
UniProt	O00444 (UniProt - Evidence at protein level)
neXtProt	NX_O00444
Antibodypedia	PLK4 antibodies

PROTEIN BROWSER

PLK4-001	PLK4-002	PLK4-003	PLK4-004	PLK4-005	PLK4-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLK4-001 ENSP00000270861 ENST00000270861	O00444 [Direct mapping] Serine/threonine-protein kinase PLK4 Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0001741 [XY body] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005730 [nucleolus] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0006996 [organelle organization] GO:0007099 [centriole replication] GO:0032154 [cleavage furrow] GO:0042802 [identical protein binding] GO:0046601 [positive regulation of centriole replication] GO:0060707 [trophoblast giant cell differentiation] GO:0098535 [de novo centriole assembly] GO:0098536 [deuterosome] Show all	970 aa 109 kDa	No	0
PLK4-002 ENSP00000423582 ENST00000514379	O00444 [Direct mapping] Serine/threonine-protein kinase PLK4 Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005730 [nucleolus] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0006996 [organelle organization] GO:0007099 [centriole replication] GO:0032154 [cleavage furrow] GO:0046601 [positive regulation of centriole replication] GO:0060707 [trophoblast giant cell differentiation] GO:0098535 [de novo centriole assembly] GO:0098536 [deuterosome] Show all	929 aa 104.6 kDa	No	0
PLK4-003 ENSP00000427554 ENST00000513090	O00444 [Direct mapping] Serine/threonine-protein kinase PLK4 Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005730 [nucleolus] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0006996 [organelle organization] GO:0007099 [centriole replication] GO:0032154 [cleavage furrow] GO:0046601 [positive regulation of centriole replication] GO:0060707 [trophoblast giant cell differentiation] GO:0098535 [de novo centriole assembly] GO:0098536 [deuterosome] Show all	938 aa 105.3 kDa	No	0
PLK4-004 ENSP00000421774 ENST00000515069	J3KR82 [Direct mapping] Serine/threonine-protein kinase PLK Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	892 aa 100.1 kDa	No	0
PLK4-005 ENSP00000423412 ENST00000507249	J3KR84 [Direct mapping] Serine/threonine-protein kinase PLK Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	909 aa 102.1 kDa	No	0
PLK4-009 ENSP00000427568 ENST00000508113	H0YAL6 [Direct mapping] Serine/threonine-protein kinase PLK4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	198 aa 21.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.