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PLK4

GENERAL INFORMATION

Gene name

 PLK4

Gene description

 Polo-like kinase 4

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA035026
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable), lung cancer (unfavourable) and pancreatic cancer (unfavourable).
Colorectal cancer p<0.001
Lung cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035026

GENE INFORMATION

Gene name

 PLK4 (HGNC Symbol)

Synonyms

 Sak, STK18

Description

 Polo-like kinase 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Chromosome

 4

Cytoband

 q28.1

Chromosome location (bp)

 127880861 - 127899195

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142731 (version 83.38)

Entrez gene

 10733

UniProt

 O00444 (UniProt - Evidence at protein level)

neXtProt

 NX_O00444

Antibodypedia

 PLK4 antibodies

PROTEIN BROWSER
PLK4-001
PLK4-002
PLK4-003
PLK4-004
PLK4-005
PLK4-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLK4-001
ENSP00000270861
ENST00000270861
O00444 [Direct mapping]
Serine/threonine-protein kinase PLK4
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
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GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0001741 [XY body]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006996 [organelle organization]
GO:0007099 [centriole replication]
GO:0032154 [cleavage furrow]
GO:0042802 [identical protein binding]
GO:0046601 [positive regulation of centriole replication]
GO:0060707 [trophoblast giant cell differentiation]
GO:0098535 [de novo centriole assembly]
GO:0098536 [deuterosome]
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 970 aa
109 kDa 		No 0
PLK4-002
ENSP00000423582
ENST00000514379
O00444 [Direct mapping]
Serine/threonine-protein kinase PLK4
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006996 [organelle organization]
GO:0007099 [centriole replication]
GO:0032154 [cleavage furrow]
GO:0046601 [positive regulation of centriole replication]
GO:0060707 [trophoblast giant cell differentiation]
GO:0098535 [de novo centriole assembly]
GO:0098536 [deuterosome]
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 929 aa
104.6 kDa 		No 0
PLK4-003
ENSP00000427554
ENST00000513090
O00444 [Direct mapping]
Serine/threonine-protein kinase PLK4
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006996 [organelle organization]
GO:0007099 [centriole replication]
GO:0032154 [cleavage furrow]
GO:0046601 [positive regulation of centriole replication]
GO:0060707 [trophoblast giant cell differentiation]
GO:0098535 [de novo centriole assembly]
GO:0098536 [deuterosome]
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 938 aa
105.3 kDa 		No 0
PLK4-004
ENSP00000421774
ENST00000515069
J3KR82 [Direct mapping]
Serine/threonine-protein kinase PLK
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 892 aa
100.1 kDa 		No 0
PLK4-005
ENSP00000423412
ENST00000507249
J3KR84 [Direct mapping]
Serine/threonine-protein kinase PLK
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 909 aa
102.1 kDa 		No 0
PLK4-009
ENSP00000427568
ENST00000508113
H0YAL6 [Direct mapping]
Serine/threonine-protein kinase PLK4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 198 aa
21.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.