Tissue expression of RGS5 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	RGS5
Gene description	Regulator of G-protein signaling 5
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	RGS5
Synonyms
Description	Regulator of G-protein signaling 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	163111121 - 163321791
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143248 (version 83.38)
Entrez gene	8490
UniProt	O15539 (UniProt - Evidence at protein level)
neXtProt	NX_O15539
Antibodypedia	RGS5 antibodies

PROTEIN BROWSER

RGS5-001	RGS5-002	RGS5-004	RGS5-006	RGS5-007	RGS5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RGS5-001 ENSP00000319308 ENST00000313961	O15539 [Direct mapping] Regulator of G-protein signaling 5 A0A024R8X9 [Target identity:100%; Query identity:100%] Regulator of G-protein signalling 5, isoform CRA_b Show all	Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0009968 [negative regulation of signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	181 aa 20.9 kDa	No	0
RGS5-002 ENSP00000356879 ENST00000367903	B1APM2 [Direct mapping] Regulator of G-protein signalling 5, isoform CRA_a; Regulator of G-protein-signaling 5 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] Show all	201 aa 23.6 kDa	No	0
RGS5-004 ENSP00000432313 ENST00000527988	O15539 [Direct mapping] Regulator of G-protein signaling 5 Show all	Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0009968 [negative regulation of signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	73 aa 8.7 kDa	No	0
RGS5-006 ENSP00000433001 ENST00000530507	O15539 [Direct mapping] Regulator of G-protein signaling 5 Show all	Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0009968 [negative regulation of signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	185 aa 21.4 kDa	No	0
RGS5-007 ENSP00000435861 ENST00000531476	E9PS96 [Direct mapping] Regulator of G-protein-signaling 5 Show all	Predicted intracellular proteins Show all	GO:0005886 [plasma membrane] Show all	71 aa 8.2 kDa	No	0
RGS5-201 ENSP00000480891 ENST00000618415	O15539 [Direct mapping] Regulator of G-protein signaling 5 Show all	Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0009968 [negative regulation of signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	73 aa 8.7 kDa	No	0