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This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
Q07820 [Direct mapping] Induced myeloid leukemia cell differentiation protein Mcl-1
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Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001709 [cell fate determination] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005829 [cytosol] GO:0007275 [multicellular organismal development] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0015266 [protein channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019725 [cellular homeostasis] GO:0034097 [response to cytokine] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051434 [BH3 domain binding] GO:0071806 [protein transmembrane transport] GO:0097136 [Bcl-2 family protein complex] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:1903378 [positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway] GO:2000811 [negative regulation of anoikis] GO:2001020 [regulation of response to DNA damage stimulus] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]