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MCL1

GENERAL INFORMATION

Gene name

 MCL1

Gene description

 Myeloid cell leukemia 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Approved based on 4 antibodies.
HPA008455 , HPA031125 , CAB002781 , CAB068195
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Thyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MCL1 (HGNC Symbol)

Synonyms

 BCL2L3, Mcl-1

Description

 Myeloid cell leukemia 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]

Chromosome

 1

Cytoband

 q21.2

Chromosome location (bp)

 150574551 - 150579738

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143384 (version 83.38)

Entrez gene

 4170

UniProt

 Q07820 (UniProt - Evidence at protein level)

neXtProt

 NX_Q07820

Antibodypedia

 MCL1 antibodies

PROTEIN BROWSER
MCL1-001
MCL1-002
MCL1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MCL1-001
ENSP00000358022
ENST00000369026
Q07820 [Direct mapping]
Induced myeloid leukemia cell differentiation protein Mcl-1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001709 [cell fate determination]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0007275 [multicellular organismal development]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0008637 [apoptotic mitochondrial changes]
GO:0015266 [protein channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019725 [cellular homeostasis]
GO:0034097 [response to cytokine]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0046982 [protein heterodimerization activity]
GO:0051434 [BH3 domain binding]
GO:0071806 [protein transmembrane transport]
GO:0097136 [Bcl-2 family protein complex]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:1903378 [positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway]
GO:2000811 [negative regulation of anoikis]
GO:2001020 [regulation of response to DNA damage stimulus]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
Show all
 350 aa
37.3 kDa 		No 1
MCL1-002
ENSP00000309973
ENST00000307940
Q07820 [Direct mapping]
Induced myeloid leukemia cell differentiation protein Mcl-1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001709 [cell fate determination]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0007275 [multicellular organismal development]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0015266 [protein channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019725 [cellular homeostasis]
GO:0034097 [response to cytokine]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046982 [protein heterodimerization activity]
GO:0051434 [BH3 domain binding]
GO:0071806 [protein transmembrane transport]
GO:0097136 [Bcl-2 family protein complex]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:1903378 [positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway]
GO:2000811 [negative regulation of anoikis]
GO:2001020 [regulation of response to DNA damage stimulus]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
Show all
 271 aa
28.7 kDa 		No 0
MCL1-201
ENSP00000477624
ENST00000620947
A0A087WT64 [Direct mapping]
Induced myeloid leukemia cell differentiation protein Mcl-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0016021 [integral component of membrane]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
Show all
 197 aa
21.2 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.