We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Strong cytoplasmic staining in most testis cancers. Weak to moderate staining in most other malignant tissues. Virtually no staining in malignant gliomas, skin and renal carcinomas.
Moderate cytoplasmic positivity was observed in most malignancies. Thyroid cancer and few malignant melanomas were strongly stained. Skin and several malignant gliomas, cervical, urothelial and renal cancers were negative or weakly stained.
Most cancers showed weak to moderate cytoplasmic immunoreactivity. A few cases of lymphoma, breast, cervical and testis cancers displayed strong positivity. Several gliomas, protate, endometrial, lung, skin, renal and liver cancer were negative.
GENE INFORMATION
Gene name
MCL1 (HGNC Symbol)
Synonyms
BCL2L3, Mcl-1
Description
Myeloid cell leukemia 1 (HGNC Symbol)
Entrez gene summary
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
Q07820 [Direct mapping] Induced myeloid leukemia cell differentiation protein Mcl-1
Show all
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001709 [cell fate determination] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005829 [cytosol] GO:0007275 [multicellular organismal development] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0015266 [protein channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019725 [cellular homeostasis] GO:0034097 [response to cytokine] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051434 [BH3 domain binding] GO:0071806 [protein transmembrane transport] GO:0097136 [Bcl-2 family protein complex] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:1903378 [positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway] GO:2000811 [negative regulation of anoikis] GO:2001020 [regulation of response to DNA damage stimulus] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]