Tissue expression of SLC39A1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLC39A1
Gene description	Solute carrier family 39 (zinc transporter), member 1
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SLC39A1 (HGNC Symbol)
Synonyms	ZIP1, ZIRTL
Description	Solute carrier family 39 (zinc transporter), member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	153959099 - 153968184
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143570 (version 83.38)
Entrez gene	27173
UniProt	Q9NY26 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NY26
Antibodypedia	SLC39A1 antibodies

PROTEIN BROWSER

SLC39A1-001	SLC39A1-002	SLC39A1-003	SLC39A1-004	SLC39A1-005	SLC39A1-006	SLC39A1-008	SLC39A1-201	SLC39A1-202	SLC39A1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC39A1-001 ENSP00000348535 ENST00000356205	Q9NY26 [Direct mapping] Zinc transporter ZIP1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022890 [inorganic cation transmembrane transporter activity] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] GO:0071577 [zinc II ion transmembrane transport] Show all	324 aa 34.2 kDa	No	8
SLC39A1-002 ENSP00000357612 ENST00000368623	Q9NY26 [Direct mapping] Zinc transporter ZIP1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001701 [in utero embryonic development] GO:0005102 [receptor binding] GO:0005385 [zinc ion transmembrane transporter activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0006829 [zinc II ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022890 [inorganic cation transmembrane transporter activity] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0048701 [embryonic cranial skeleton morphogenesis] GO:0055085 [transmembrane transport] GO:0060173 [limb development] GO:0071577 [zinc II ion transmembrane transport] Show all	324 aa 34.2 kDa	No	8
SLC39A1-003 ENSP00000309710 ENST00000310483	Q9NY26 [Direct mapping] Zinc transporter ZIP1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022890 [inorganic cation transmembrane transporter activity] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] GO:0071577 [zinc II ion transmembrane transport] Show all	324 aa 34.2 kDa	No	8
SLC39A1-004 ENSP00000357610 ENST00000368621	Q9NY26 [Direct mapping] Zinc transporter ZIP1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022890 [inorganic cation transmembrane transporter activity] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] GO:0071577 [zinc II ion transmembrane transport] Show all	324 aa 34.2 kDa	No	8
SLC39A1-005 ENSP00000392229 ENST00000413622	Q5T4K4 [Direct mapping] Zinc transporter ZIP1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	240 aa 25.5 kDa	No	4
SLC39A1-006 ENSP00000392950 ENST00000429040	Q5T4K3 [Direct mapping] Zinc transporter ZIP1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	321 aa 33.9 kDa	No	8
SLC39A1-008 ENSP00000407717 ENST00000417348	Q5T4K2 [Direct mapping] Zinc transporter ZIP1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	206 aa 21.8 kDa	No	3
SLC39A1-201 ENSP00000443632 ENST00000537590	A0A0A0MTL8 [Direct mapping] Zinc transporter ZIP1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	116 aa 11.8 kDa	No	0
SLC39A1-202 ENSP00000479421 ENST00000617697	Q9NY26 [Direct mapping] Zinc transporter ZIP1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022890 [inorganic cation transmembrane transporter activity] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] GO:0071577 [zinc II ion transmembrane transport] Show all	324 aa 34.2 kDa	No	8
SLC39A1-203 ENSP00000484182 ENST00000621013	Q9NY26 [Direct mapping] Zinc transporter ZIP1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022890 [inorganic cation transmembrane transporter activity] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] GO:0071577 [zinc II ion transmembrane transport] Show all	324 aa 34.2 kDa	No	8