Few cases of endometrial along with rare breast, thyroid, lung and renal cancers exhibited moderate cytoplasmic positivity. Hepatocellular carcinomas showed moderate positivity. Remaining cancers were weakly satined or negative.
Most of hepatocellular carcinomas and a case of follicular adenoma carcinoma of thyroid displayed strong cytoplasmic staining. Few endometrial cancers and duct carcinomas of breast displayed moderate cytoplasmic staining. Remaining cancer tissues were negative.
Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]