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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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EPHX1
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

EPHX1

Gene description

Epoxide hydrolase 1, microsomal (xenobiotic)

Protein class

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enhanced (SiHa)
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in hepatocytes, exocrine pancreas, adrenal gland and Leydig cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA020593 , HPA048847
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in lung cancer (favourable) and prostate cancer (favourable).
Lung cancer p<0.001
Prostate cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA020593
HPA048847

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few cases of endometrial along with rare breast, thyroid, lung and renal cancers exhibited moderate cytoplasmic positivity. Hepatocellular carcinomas showed moderate positivity. Remaining cancers were weakly satined or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most of hepatocellular carcinomas and a case of follicular adenoma carcinoma of thyroid displayed strong cytoplasmic staining. Few endometrial cancers and duct carcinomas of breast displayed moderate cytoplasmic staining. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

EPHX1 (HGNC Symbol)

Synonyms

EPHX

Description

Epoxide hydrolase 1, microsomal (xenobiotic) (HGNC Symbol)

Entrez gene summary

Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]

Chromosome

1

Cytoband

q42.12

Chromosome location (bp)

225810092 - 225845563

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143819 (version 83.38)

Entrez gene

2052

UniProt

P07099 (UniProt - Evidence at protein level)

neXtProt

NX_P07099

Antibodypedia

EPHX1 antibodies

PROTEIN BROWSER

EPHX1-001
EPHX1-002
EPHX1-003
EPHX1-201
EPHX1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EPHX1-001
ENSP00000355802
ENST00000366837
P07099 [Direct mapping]
Epoxide hydrolase 1
R4SBI6 [Target identity:100%; Query identity:100%]
EPHX1; Epoxide hydrolase 1, microsomal (Xenobiotic), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   SignalP predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004301 [epoxide hydrolase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006805 [xenobiotic metabolic process]
GO:0009636 [response to toxic substance]
GO:0016021 [integral component of membrane]
GO:0019439 [aromatic compound catabolic process]
GO:0033961 [cis-stilbene-oxide hydrolase activity]
GO:0044281 [small molecule metabolic process]
Show all
455 aa
52.9 kDa
No 0
EPHX1-002
ENSP00000398491
ENST00000445856
B1AQP9 [Direct mapping]
Epoxide hydrolase 1
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   SignalP predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
161 aa
19.3 kDa
No 0
EPHX1-003
ENSP00000408469
ENST00000448202
B1AQP8 [Direct mapping]
Epoxide hydrolase 1
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   SignalP predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
136 aa
16.4 kDa
No 0
EPHX1-201
ENSP00000272167
ENST00000272167
P07099 [Direct mapping]
Epoxide hydrolase 1
R4SBI6 [Target identity:100%; Query identity:100%]
EPHX1; Epoxide hydrolase 1, microsomal (Xenobiotic), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   SignalP predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004301 [epoxide hydrolase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006805 [xenobiotic metabolic process]
GO:0009636 [response to toxic substance]
GO:0016021 [integral component of membrane]
GO:0019439 [aromatic compound catabolic process]
GO:0033961 [cis-stilbene-oxide hydrolase activity]
GO:0044281 [small molecule metabolic process]
Show all
455 aa
52.9 kDa
No 0
EPHX1-202
ENSP00000480004
ENST00000614058
P07099 [Direct mapping]
Epoxide hydrolase 1
R4SBI6 [Target identity:100%; Query identity:100%]
EPHX1; Epoxide hydrolase 1, microsomal (Xenobiotic), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   SignalP predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004301 [epoxide hydrolase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006725 [cellular aromatic compound metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0009636 [response to toxic substance]
GO:0014070 [response to organic cyclic compound]
GO:0016021 [integral component of membrane]
GO:0019439 [aromatic compound catabolic process]
GO:0033961 [cis-stilbene-oxide hydrolase activity]
GO:0044281 [small molecule metabolic process]
Show all
455 aa
52.9 kDa
No 0

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