Expression of EPHX1 in cancer - Summary

GENERAL INFORMATION
Gene name	EPHX1
Gene description	Epoxide hydrolase 1, microsomal (xenobiotic)
Protein class	Cancer-related genes Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enhanced (SiHa)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in hepatocytes, exocrine pancreas, adrenal gland and Leydig cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA020593 , HPA048847
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable) and prostate cancer (favourable).
Lung cancer p<0.001 Prostate cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA020593	HPA048847

GENE INFORMATION
Gene name	EPHX1 (HGNC Symbol)
Synonyms	EPHX
Description	Epoxide hydrolase 1, microsomal (xenobiotic) (HGNC Symbol)
Entrez gene summary	Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]
Chromosome	1
Cytoband	q42.12
Chromosome location (bp)	225810092 - 225845563
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143819 (version 83.38)
Entrez gene	2052
UniProt	P07099 (UniProt - Evidence at protein level)
neXtProt	NX_P07099
Antibodypedia	EPHX1 antibodies

PROTEIN BROWSER

EPHX1-001	EPHX1-002	EPHX1-003	EPHX1-201	EPHX1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EPHX1-001 ENSP00000355802 ENST00000366837	P07099 [Direct mapping] Epoxide hydrolase 1 R4SBI6 [Target identity:100%; Query identity:100%] EPHX1; Epoxide hydrolase 1, microsomal (Xenobiotic), isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004301 [epoxide hydrolase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0009636 [response to toxic substance] GO:0016021 [integral component of membrane] GO:0019439 [aromatic compound catabolic process] GO:0033961 [cis-stilbene-oxide hydrolase activity] GO:0044281 [small molecule metabolic process] Show all	455 aa 52.9 kDa	No	0
EPHX1-002 ENSP00000398491 ENST00000445856	B1AQP9 [Direct mapping] Epoxide hydrolase 1 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		161 aa 19.3 kDa	No	0
EPHX1-003 ENSP00000408469 ENST00000448202	B1AQP8 [Direct mapping] Epoxide hydrolase 1 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		136 aa 16.4 kDa	No	0
EPHX1-201 ENSP00000272167 ENST00000272167	P07099 [Direct mapping] Epoxide hydrolase 1 R4SBI6 [Target identity:100%; Query identity:100%] EPHX1; Epoxide hydrolase 1, microsomal (Xenobiotic), isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004301 [epoxide hydrolase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0009636 [response to toxic substance] GO:0016021 [integral component of membrane] GO:0019439 [aromatic compound catabolic process] GO:0033961 [cis-stilbene-oxide hydrolase activity] GO:0044281 [small molecule metabolic process] Show all	455 aa 52.9 kDa	No	0
EPHX1-202 ENSP00000480004 ENST00000614058	P07099 [Direct mapping] Epoxide hydrolase 1 R4SBI6 [Target identity:100%; Query identity:100%] EPHX1; Epoxide hydrolase 1, microsomal (Xenobiotic), isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004301 [epoxide hydrolase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006725 [cellular aromatic compound metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0009636 [response to toxic substance] GO:0014070 [response to organic cyclic compound] GO:0016021 [integral component of membrane] GO:0019439 [aromatic compound catabolic process] GO:0033961 [cis-stilbene-oxide hydrolase activity] GO:0044281 [small molecule metabolic process] Show all	455 aa 52.9 kDa	No	0