Tissue expression of EPHX1 - Summary - The Human Protein Atlas

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EPHX1

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	EPHX1
Gene description	Epoxide hydrolase 1, microsomal (xenobiotic)
Protein class	Cancer-related genes Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in hepatocytes, exocrine pancreas, adrenal gland and Leydig cells.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA020593 , HPA048847
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	EPHX1 (HGNC Symbol)
Synonyms	EPHX
Description	Epoxide hydrolase 1, microsomal (xenobiotic) (HGNC Symbol)
Entrez gene summary	Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]
Chromosome	1
Cytoband	q42.12
Chromosome location (bp)	225810092 - 225845563
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143819 (version 83.38)
Entrez gene	2052
UniProt	P07099 (UniProt - Evidence at protein level)
neXtProt	NX_P07099
Antibodypedia	EPHX1 antibodies

PROTEIN BROWSER

EPHX1-001	EPHX1-002	EPHX1-003	EPHX1-201	EPHX1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EPHX1-001 ENSP00000355802 ENST00000366837	P07099 [Direct mapping] Epoxide hydrolase 1 R4SBI6 [Target identity:100%; Query identity:100%] EPHX1; Epoxide hydrolase 1, microsomal (Xenobiotic), isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004301 [epoxide hydrolase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0009636 [response to toxic substance] GO:0016021 [integral component of membrane] GO:0019439 [aromatic compound catabolic process] GO:0033961 [cis-stilbene-oxide hydrolase activity] GO:0044281 [small molecule metabolic process] Show all	455 aa 52.9 kDa	No	0
EPHX1-002 ENSP00000398491 ENST00000445856	B1AQP9 [Direct mapping] Epoxide hydrolase 1 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		161 aa 19.3 kDa	No	0
EPHX1-003 ENSP00000408469 ENST00000448202	B1AQP8 [Direct mapping] Epoxide hydrolase 1 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		136 aa 16.4 kDa	No	0
EPHX1-201 ENSP00000272167 ENST00000272167	P07099 [Direct mapping] Epoxide hydrolase 1 R4SBI6 [Target identity:100%; Query identity:100%] EPHX1; Epoxide hydrolase 1, microsomal (Xenobiotic), isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004301 [epoxide hydrolase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0009636 [response to toxic substance] GO:0016021 [integral component of membrane] GO:0019439 [aromatic compound catabolic process] GO:0033961 [cis-stilbene-oxide hydrolase activity] GO:0044281 [small molecule metabolic process] Show all	455 aa 52.9 kDa	No	0
EPHX1-202 ENSP00000480004 ENST00000614058	P07099 [Direct mapping] Epoxide hydrolase 1 R4SBI6 [Target identity:100%; Query identity:100%] EPHX1; Epoxide hydrolase 1, microsomal (Xenobiotic), isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004301 [epoxide hydrolase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006725 [cellular aromatic compound metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0009636 [response to toxic substance] GO:0014070 [response to organic cyclic compound] GO:0016021 [integral component of membrane] GO:0019439 [aromatic compound catabolic process] GO:0033961 [cis-stilbene-oxide hydrolase activity] GO:0044281 [small molecule metabolic process] Show all	455 aa 52.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.