Fields »
ABOUT
HELP
BLOG
DCDC2

GENERAL INFORMATION

Gene name

 DCDC2

Gene description

 Doublecortin domain containing 2

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (kidney)
GTEx:Group enriched (kidney, pancreas, testis, thyroid gland)
FANTOM5:Tissue enhanced (epididymis, kidney)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, most abundant in cells in renal tubules and cilia in fallopian tube.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending retesting.

Reliability score

 Supported based on 2 antibodies.
HPA031582 , HPA031583
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (kidney, pancreas, testis, thyroid gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (epididymis, kidney)

GENE INFORMATION

Gene name

 DCDC2 (HGNC Symbol)

Synonyms

 DCDC2A, KIAA1154, NPHP19, RU2

Description

 Doublecortin domain containing 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2013]

Chromosome

 6

Cytoband

 p22.3

Chromosome location (bp)

 24171756 - 24358052

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146038 (version 83.38)

Entrez gene

 51473

UniProt

 Q9UHG0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHG0

Antibodypedia

 DCDC2 antibodies

PROTEIN BROWSER
DCDC2-001
DCDC2-002
DCDC2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DCDC2-001
ENSP00000367715
ENST00000378454
Q9UHG0 [Direct mapping]
Doublecortin domain-containing protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005930 [axoneme]
GO:0006968 [cellular defense response]
GO:0008542 [visual learning]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0045880 [positive regulation of smoothened signaling pathway]
GO:0048813 [dendrite morphogenesis]
GO:0072372 [primary cilium]
Show all
 476 aa
52.8 kDa 		No 0
DCDC2-002
ENSP00000367711
ENST00000378450
Q9UHG0 [Direct mapping]
Doublecortin domain-containing protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005930 [axoneme]
GO:0006968 [cellular defense response]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0045880 [positive regulation of smoothened signaling pathway]
GO:0072372 [primary cilium]
Show all
 229 aa
25.6 kDa 		No 0
DCDC2-003
ENSP00000410939
ENST00000436313
H0Y784 [Direct mapping]
Doublecortin domain-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0035556 [intracellular signal transduction]
Show all
 88 aa
9.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.