Expression of IGFBP1 in cancer - Summary - The Human Protein Atlas

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IGFBP1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IGFBP1
Gene description	Insulin-like growth factor binding protein 1
Protein class	Candidate cardiovascular disease genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Group enriched (Hep G2, U-2197, U-87 MG)
HPA (normal tissue):	Group enriched (endometrium, liver, placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in decidual cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 3 antibodies. HPA046972 , HPA050640 , CAB004445
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), lung cancer (unfavourable) and stomach cancer (unfavourable).
Renal cancer p<0.001 Lung cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046972	HPA050640	CAB004445

GENE INFORMATION
Gene name	IGFBP1 (HGNC Symbol)
Synonyms	AFBP, hIGFBP-1, IBP1, IGF-BP25, PP12
Description	Insulin-like growth factor binding protein 1 (HGNC Symbol)
Entrez gene summary	This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	p12.3
Chromosome location (bp)	45888357 - 45893668
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146678 (version 83.38)
Entrez gene	3484
UniProt	P08833 (UniProt - Evidence at protein level)
neXtProt	NX_P08833
Antibodypedia	IGFBP1 antibodies

PROTEIN BROWSER

IGFBP1-001	IGFBP1-002	IGFBP1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IGFBP1-001 ENSP00000275525 ENST00000275525	P08833 [Direct mapping] Insulin-like growth factor-binding protein 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0008286 [insulin receptor signaling pathway] GO:0030307 [positive regulation of cell growth] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0031994 [insulin-like growth factor I binding] GO:0031995 [insulin-like growth factor II binding] GO:0036499 [PERK-mediated unfolded protein response] GO:0042246 [tissue regeneration] GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway] GO:0044267 [cellular protein metabolic process] Show all	259 aa 27.9 kDa	Yes	0
IGFBP1-002 ENSP00000413511 ENST00000457280	C9JXF9 [Direct mapping] Insulin-like growth factor-binding protein 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0031994 [insulin-like growth factor I binding] GO:0031995 [insulin-like growth factor II binding] GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway] Show all	257 aa 27.7 kDa	Yes	0
IGFBP1-003 ENSP00000417069 ENST00000468955	C9J6H2 [Direct mapping] Insulin-like growth factor-binding protein 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0031994 [insulin-like growth factor I binding] GO:0031995 [insulin-like growth factor II binding] GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway] Show all	216 aa 22.9 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.