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Gene name

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Chromosome

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In atlas

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Reliability

Reliability

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Method

Validation

Method

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Cancer

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Detectable

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Detectable

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IGFBP1
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    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

IGFBP1

Gene description

Insulin-like growth factor binding protein 1

Protein class

Candidate cardiovascular disease genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (endometrium, liver, placenta)
GTEx:Tissue enriched (liver)
FANTOM5:Group enriched (liver, placenta)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in decidual cells.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Supported based on 3 antibodies.
HPA046972 , HPA050640 , CAB004445
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (endometrium, liver, placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, placenta)

GENE INFORMATION

Gene name

IGFBP1 (HGNC Symbol)

Synonyms

AFBP, hIGFBP-1, IBP1, IGF-BP25, PP12

Description

Insulin-like growth factor binding protein 1 (HGNC Symbol)

Entrez gene summary

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

p12.3

Chromosome location (bp)

45888357 - 45893668

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000146678 (version 83.38)

Entrez gene

3484

UniProt

P08833 (UniProt - Evidence at protein level)

neXtProt

NX_P08833

Antibodypedia

IGFBP1 antibodies

PROTEIN BROWSER

IGFBP1-001
IGFBP1-002
IGFBP1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IGFBP1-001
ENSP00000275525
ENST00000275525
P08833 [Direct mapping]
Insulin-like growth factor-binding protein 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0030307 [positive regulation of cell growth]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031994 [insulin-like growth factor I binding]
GO:0031995 [insulin-like growth factor II binding]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042246 [tissue regeneration]
GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway]
GO:0044267 [cellular protein metabolic process]
Show all
259 aa
27.9 kDa
Yes 0
IGFBP1-002
ENSP00000413511
ENST00000457280
C9JXF9 [Direct mapping]
Insulin-like growth factor-binding protein 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
GO:0031994 [insulin-like growth factor I binding]
GO:0031995 [insulin-like growth factor II binding]
GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway]
Show all
257 aa
27.7 kDa
Yes 0
IGFBP1-003
ENSP00000417069
ENST00000468955
C9J6H2 [Direct mapping]
Insulin-like growth factor-binding protein 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
GO:0031994 [insulin-like growth factor I binding]
GO:0031995 [insulin-like growth factor II binding]
GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway]
Show all
216 aa
22.9 kDa
Yes 0

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