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SYTL5

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GENERAL INFORMATION

Gene name

 SYTL5

Gene description

 Synaptotagmin-like 5

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol & microtubules.

RNA cell category

 Cell line enhanced (SK-MEL-30, CACO-2, U-2 OS, MCF7)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved)

Additional location

 In addition localized to the Microtubules (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA026074
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SK-MEL-30, CACO-2, U-2 OS, MCF7)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol & microtubules.

Main location

 Nucleoplasm (approved)

Additional location

 Microtubules (approved), Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA026074 A-431 Nucleoplasm
Microtubules
Cytosol
HPA026074 U-2 OS Nucleoplasm
Microtubules
Cytosol
HPA026074 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 SYTL5

Synonyms

Description

 Synaptotagmin-like 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the synaptotagmin-like (Slp) protein family, which contains a unique homology domain at the N-terminus, referred to as the Slp homology domain (SHD). The SHD functions as a binding site for Rab27A, which plays a role in protein transport. Expression of this gene is restricted to placenta and liver, suggesting that it might be involved in Rab27A-dependent membrane trafficking in specific tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

 X

Cytoband

 p11.4

Chromosome location (bp)

 38006582 - 38128819

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147041 (version 83.38)

Entrez gene

 94122

UniProt

 Q8TDW5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TDW5

Antibodypedia

 SYTL5 antibodies

PROTEIN BROWSER
SYTL5-001
SYTL5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SYTL5-001
ENSP00000297875
ENST00000297875
Q8TDW5 [Direct mapping]
Synaptotagmin-like protein 5
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017137 [Rab GTPase binding]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
GO:0070382 [exocytic vesicle]
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 730 aa
81.5 kDa 		No 0
SYTL5-201
ENSP00000395220
ENST00000456733
Q8TDW5 [Direct mapping]
Synaptotagmin-like protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017137 [Rab GTPase binding]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
GO:0070382 [exocytic vesicle]
Show all
 752 aa
83.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.