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SYTL5

GENERAL INFORMATION

Gene name

 SYTL5

Gene description

 Synaptotagmin-like 5

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (CACO-2, MCF7, SK-MEL-30, U-2 OS)
HPA (normal tissue):Tissue enhanced (stomach)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA026074
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA026074

GENE INFORMATION

Gene name

 SYTL5

Synonyms

Description

 Synaptotagmin-like 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the synaptotagmin-like (Slp) protein family, which contains a unique homology domain at the N-terminus, referred to as the Slp homology domain (SHD). The SHD functions as a binding site for Rab27A, which plays a role in protein transport. Expression of this gene is restricted to placenta and liver, suggesting that it might be involved in Rab27A-dependent membrane trafficking in specific tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

 X

Cytoband

 p11.4

Chromosome location (bp)

 38006582 - 38128819

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147041 (version 83.38)

Entrez gene

 94122

UniProt

 Q8TDW5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TDW5

Antibodypedia

 SYTL5 antibodies

PROTEIN BROWSER
SYTL5-001
SYTL5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SYTL5-001
ENSP00000297875
ENST00000297875
Q8TDW5 [Direct mapping]
Synaptotagmin-like protein 5
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
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GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017137 [Rab GTPase binding]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
GO:0070382 [exocytic vesicle]
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 730 aa
81.5 kDa 		No 0
SYTL5-201
ENSP00000395220
ENST00000456733
Q8TDW5 [Direct mapping]
Synaptotagmin-like protein 5
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017137 [Rab GTPase binding]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
GO:0070382 [exocytic vesicle]
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 752 aa
83.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.